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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202106390
|2 doi
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|a pubmed24n1110.xml
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|a eng
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| 100 |
1 |
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|a Zhao, Hao
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Tailoring Aggregation Extent of Photosensitizers to Boost Phototherapy Potency for Eliciting Systemic Antitumor Immunity
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|c 2022
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 31.03.2022
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|a Date Revised 01.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Phototherapy is effective for triggering the immunogenic cell death (ICD) effect. However, its efficacy is limited by low 1 O2 generation and photothermal conversion efficacy due to two irreconcilable obstacles, namely the aggregation-caused-quenching (ACQ) effect and photobleaching. In this work, a discretely integrated nanofabrication (DIN) platform (Pt-ICG/PES) is developed by facile coordination coassembly of cisplatin (Pt), photosensitizer molecules (indocyanine green (ICG)), and polymeric spacer (p(MEO2 MA-co-OEGMA)-b-pSS (PES)). By controlling the ICG/PES feeding ratio, the aggregation of ICG can be easily tailored using PES as an isolator to balance the ACQ effect and photobleaching, thereby maximizing the phototherapy potency of Pt-ICG/PES. With the optimized ratio of each component, Pt-ICG/PES integrates the complementarity of photodynamic therapy, photothermal therapy, and chemotherapeutics to magnify the ICD effect, exerting a synergistic antitumor immunity-promoting effect. Additionally, temperature-sensitive PES enables photothermally guided drug delivery. In a tumor-bearing mouse model, Pt-ICG/PES elicits effective release of danger-associated molecular patterns, dendritic cell maturation, cytotoxic T lymphocytes activation, cytokine secretion, M2 macrophage repolarization, and distal tumor suppression, confirming the excellent in situ tumor ICD effect as well as robust systematic antitumor immunity. Ultimately, a versatile DIN strategy is developed to optimize the phototherapeutic efficacy for improving antitumor effects and strengthening systemic antitumor immunity
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|a Journal Article
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|a antitumor immunity
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|a chemotherapy
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|a discrete integration
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|a immunogenic cell death
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4 |
|a phototherapy
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| 650 |
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|a Photosensitizing Agents
|2 NLM
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| 650 |
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|a Indocyanine Green
|2 NLM
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| 650 |
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7 |
|a IX6J1063HV
|2 NLM
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| 700 |
1 |
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|a Xu, Jiabao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Chan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ren, Jiayu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bao, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yanbing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tao, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yuliang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Xiangliang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 8 vom: 10. Feb., Seite e2106390
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|g volume:34
|g year:2022
|g number:8
|g day:10
|g month:02
|g pages:e2106390
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|u http://dx.doi.org/10.1002/adma.202106390
|3 Volltext
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