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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202107161
|2 doi
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|a pubmed24n1110.xml
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|a eng
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| 100 |
1 |
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|a Zhao, Yu
|e verfasserin
|4 aut
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| 245 |
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|a Stapled Liposomes Enhance Cross-Priming of Radio-Immunotherapy
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 31.03.2022
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|a Date Revised 01.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a The release of tumor-associated antigens (TAAs) and their cross-presentation in dendritic cells (DCs) are crucial for radio-immunotherapy. However, the irradiation resistance of tumor cells usually results in limited TAA generation and release. Importantly, TAAs internalized by DCs are easily degraded in lysosomes, resulting in unsatisfactory extent of TAA cross-presentation. Herein, an antigen-capturing stapled liposome (ACSL) with a robust structure and bioactive surface is developed. The ACSLs capture and transport TAAs from lysosomes to the cytoplasm in DCs, thereby enhancing TAA cross-presentation. l-arginine encapsulated in ACSLs induces robust T cell-dependent antitumor response and immune memory in 4T1 tumor-bearing mice after local irradiation, resulting in significant tumor suppression and an abscopal effect. Replacing l-arginine with radiosensitizers, photosensitizers, and photothermal agents may make ACSL a universal platform for the rapid development of various combinations of anticancer therapies
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|a Journal Article
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|a bioactive surfaces
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|a cross-presentation
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|a physicochemical stability
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|a radio-immunotherapy
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|a stapled liposomes
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|a Antigens, Neoplasm
|2 NLM
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| 650 |
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|a Liposomes
|2 NLM
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| 700 |
1 |
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|a Hou, Xiaoxue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chai, Jingshan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhanzhan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xue, Xue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Fan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Jianfeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Linqi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yang
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 3 vom: 10. Jan., Seite e2107161
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:34
|g year:2022
|g number:3
|g day:10
|g month:01
|g pages:e2107161
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|u http://dx.doi.org/10.1002/adma.202107161
|3 Volltext
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