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|a 10.1134/S1070363221090231
|2 doi
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|a eng
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|a Abdel-Latif, E
|e verfasserin
|4 aut
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|a Synthesis of New Binary Thiazole-Based Heterocycles and Their Molecular Docking Study as COVID-19 Main Protease (Mpro) Inhibitors
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Revised 02.11.2021
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © Pleiades Publishing, Ltd. 2021.
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|a Isolated polynuclear binary heterocyclic compounds containing thiazole building block combined with benzofuran, pyrrole, thiazole, or thiophene via carboxamide and/or secondary amine as a junction are presented. The synthetic strategy of those is based on utilization of 2-chloroacetamido-4-phenylthiazole in the synthesis of binary heterocyclic compounds by cyclocondensation with salicylic aldehyde, acetonitrile derivatives, ammonium thiocyanate, 3-mercaptoacrylonitrile derivatives, and/or 3-mercaptoacrylate derivatives. The prepared binary thiazole-based heterocycles have been studied as protease (Mpro) inhibitors by molecular docking for visualization of their orientation and interactions with COVID-19 units using hydroxychloroquine as a reference molecule
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|a Journal Article
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|a COVID-19
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|a benzofuran
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|a binary heterocycles
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4 |
|a chloroacetamide
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| 650 |
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|a protease
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| 650 |
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|a thiazole
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| 700 |
1 |
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|a Khatab, T K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fekri, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Khalifa, M E
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Russian journal of general chemistry
|d 1998
|g 91(2021), 9 vom: 14., Seite 1767-1773
|w (DE-627)NLM098237942
|x 1070-3632
|7 nnas
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| 773 |
1 |
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|g volume:91
|g year:2021
|g number:9
|g day:14
|g pages:1767-1773
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|u http://dx.doi.org/10.1134/S1070363221090231
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