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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.1c02049
|2 doi
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|a pubmed24n1108.xml
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|a (DE-627)NLM332524035
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|a (NLM)34714094
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Liu, Peng
|e verfasserin
|4 aut
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| 245 |
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|a pH-Sensitive Dextran-Based Micelles from Copper-Free Click Reaction for Antitumor Drug Delivery
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 27.01.2022
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|a Date Revised 27.01.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a There remains a need to develop new strategies to fabricate dextran-based biocompatible drug delivery systems for safe and effective chemotherapy. Herein, a copper-free azide-propiolate ester click reaction was introduced for dextran modification to fabricate a pH-sensitive dextran-based drug delivery system. A pH-sensitive dextran-based micelle system, self-assembled from amphiphilic dextran-graft-poly(2-(diisopropylamino)ethyl methacrylate-co-2-(2',3',5'-triiodobenzoyl)ethyl methacrylate) or dextran-g-P(DPA-co-TIBMA), is reported for effective chemotherapy. The amphiphilic dextran-g-P(DPA-co-TIBMA) was prepared via reversible addition-fragmentation chain-transfer (RAFT) polymerization and copper-free azide-propiolate ester click reaction. Doxorubicin (DOX)-loaded dextran-g-P(DPA-co-TIBMA) micelles were prepared through self-assembly of DOX and dextran-g-P(DPA-co-TIBMA) in aqueous solution, and had a mean diameter of 154 nm and a drug loading content of 9.7 wt %. The release of DOX from DOX-loaded dextran-g-P(PDPA-co-TIBMA) micelles was slow at pH 7.4, but was greatly accelerated under acidic conditions (pH 6 and 5). Confocal laser scanning microscopy and flow cytometry experiments showed that the dextran-g-P(DPA-co-TIBMA) micelles could effectively deliver and release DOX in human breast cancer cell line (MCF-7 cells). MTT assay showed that dextran-g-P(DPA-co-TIBMA) exhibited excellent biocompatibility while DOX-loaded dextran-g-P(DPA-co-TIBMA) micelles have good antitumor efficacy in vitro. The in vivo therapeutic studies indicated that the DOX-loaded dextran-g-P(PDPA-co-TIBMA) micelles could effectively reduce the growth of tumor with little body weight reduction
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antineoplastic Agents
|2 NLM
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|a Dextrans
|2 NLM
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| 650 |
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|a Drug Carriers
|2 NLM
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| 650 |
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|a Micelles
|2 NLM
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| 650 |
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|a Doxorubicin
|2 NLM
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| 650 |
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|a 80168379AG
|2 NLM
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| 700 |
1 |
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|a Huang, Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kang, En-Tang
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 37(2021), 44 vom: 09. Nov., Seite 12990-12999
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:37
|g year:2021
|g number:44
|g day:09
|g month:11
|g pages:12990-12999
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|u http://dx.doi.org/10.1021/acs.langmuir.1c02049
|3 Volltext
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