|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM331955598 |
| 003 |
DE-627 |
| 005 |
20250302141809.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2021 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.202106317
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1106.xml
|
| 035 |
|
|
|a (DE-627)NLM331955598
|
| 035 |
|
|
|a (NLM)34655105
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Liu, Zhirong
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Cell-Traction-Triggered On-Demand Electrical Stimulation for Neuron-Like Differentiation
|
| 264 |
|
1 |
|c 2021
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 24.07.2024
|
| 500 |
|
|
|a Date Revised 24.07.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2021 Wiley-VCH GmbH.
|
| 520 |
|
|
|a Electromechanical interaction of cells and extracellular matrix are ubiquitous in biological systems. Understanding the fundamentals of this interaction and feedback is critical to design next-generation electroactive tissue engineering scaffold. Herein, based on elaborately modulating the dynamic mechanical forces in cell microenvironment, the design of a smart piezoelectric scaffold with suitable stiffness analogous to that of collagen for on-demand electrical stimulation is reported. Specifically, it generated a piezoelectric potential, namely a piezopotential, to stimulate stem cell differentiation with cell traction as a loop feedback signal, thereby avoiding the unfavorable effect of early electrical stimulation on cell spreading and adhesion. This is the first time to adapt to the dynamic microenvironment of cells and meet the electrical stimulation of cells in different states by a constant scaffold, diminishing the cumbersomeness of inducing material transformation or trigging by an external stimulus. This in situ on-demand electrical stimulation based on cell-traction-mediated piezopotential paves the way for smart scaffolds design and future bioelectronic therapies
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a dynamic microenvironment
|
| 650 |
|
4 |
|a feedback
|
| 650 |
|
4 |
|a on-demand electrostimulation
|
| 650 |
|
4 |
|a piezoelectric scaffold
|
| 650 |
|
4 |
|a stem cell differentiation
|
| 700 |
1 |
|
|a Cai, Mingjun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Xiaodi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yu, Xin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Shu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wan, Xingyi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Zhong Lin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Linlin
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 51 vom: 15. Dez., Seite e2106317
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
|
| 773 |
1 |
8 |
|g volume:33
|g year:2021
|g number:51
|g day:15
|g month:12
|g pages:e2106317
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.202106317
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 33
|j 2021
|e 51
|b 15
|c 12
|h e2106317
|