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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202105351
|2 doi
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|a pubmed24n1481.xml
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|a (NLM)34647345
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|a DE-627
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|a eng
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| 100 |
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|a Wang, Longchen
|e verfasserin
|4 aut
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|a Guiding Drug Through Interrupted Bloodstream for Potentiated Thrombolysis by C-Shaped Magnetic Actuation System In Vivo
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Fast and effective thrombolysis using tissue plasminogen activator (tPA) is limited by the poor delivery efficiency of thrombolytic drugs, which is induced by an interrupted bloodstream and delayed recanalization. Existing magnetic micro/nanodrug-loaded robots used for targeted thrombotic therapy are limited by the complexity of the clinical verification of nanodrugs and the limited space of magnetic actuation systems. Herein, a general drug delivery strategy based on mass transportation theory for thrombolysis is presented, and an open space C-shaped magnetic actuation system with laser location and ultrasound imaging navigation for in vivo evaluation is developed. tPA can be guided through an interrupted bloodstream to the thrombi by the locomotion of magnetic nanoparticle swarms (MNSs), thereby improving the thrombolysis efficacy. Notably, this strategy is able to quickly establish a life channel to achieve time-critical recanalization, which is typically inaccessible using native tPA. Both in vitro and in vivo thrombolysis experiments demonstrate that the thrombus lysis efficacy significantly increases after the application of the MNS under a rotating magnetic field. This study provides an anticipated C-shaped magnetic actuation system for in vivo validation and also presents a clinically feasible drug delivery strategy for targeted thrombolytic therapy with minimal systemic tPA exposure
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|a Journal Article
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|a C-shaped magnetic actuation systems
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|a drug delivery
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|a magnetic micro/nanorobots
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|a magnetic nanoparticle swarms
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| 650 |
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|a thrombolysis
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| 650 |
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|a Tissue Plasminogen Activator
|2 NLM
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| 650 |
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|a EC 3.4.21.68
|2 NLM
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| 650 |
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|a Fibrinolytic Agents
|2 NLM
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| 650 |
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|a Magnetite Nanoparticles
|2 NLM
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| 700 |
1 |
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|a Wang, Jienan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hao, Junnian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Ziliang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Jianrong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Guofeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ying, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Liangzhu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cai, Xiaojun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Zhuang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Yuanyi
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 51 vom: 24. Dez., Seite e2105351
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:33
|g year:2021
|g number:51
|g day:24
|g month:12
|g pages:e2105351
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202105351
|3 Volltext
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