Microbially Catalyzed Biomaterials for Bone Regeneration

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 49 vom: 11. Dez., Seite e2104829
1. Verfasser:	Li, Mengmeng (VerfasserIn)
Weitere Verfasser:	Ma, Hongshi, Han, Fei, Zhai, Dong, Zhang, Bingjun, Sun, Yuhua, Li, Tian, Chen, Lei, Wu, Chengtie
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2021
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article biomaterials bone regeneration micro/nanostructures microbial catalysis Biocompatible Materials Durapatite 91D9GV0Z28

Beschreibung
Zusammenfassung:	© 2021 Wiley-VCH GmbH. Bone is a complex mineralized tissue composed of various organic (proteins, cells) and inorganic (hydroxyapatite, calcium carbonate) substances with micro/nanoscale structures. To improve interfacial bioactivity of bone-implanted biomaterials, extensive efforts are being made to fabricate favorable biointerface via surface modification. Inspired by microbially catalyzed mineralization, a novel concept to biologically synthesize the micro/nanostructures on bioceramics, microbial-assisted catalysis, is presented. It involves three processes: bacterial adhesion on biomaterials, production of CO3 2- assisted by bacteria, and nucleation and growth of CaCO3 nanocrystals on the surface of bioceramics. The microbially catalyzed biominerals exhibit relatively uniform micro/nanostructures on the surface of both 2D and 3D α-CaSiO3 bioceramics. The topographic and chemical cues of the grown micro/nanostructures present excellent in vitro and in vivo bone-forming bioactivity. The underlying mechanism is closely related to the activation of multiple biological processes associated with bone regeneration. The study offers a microbially catalytic concept and strategy of fabricating micro/nanostructured biomaterials for tissue regeneration
Beschreibung:	Date Completed 23.05.2022 Date Revised 23.05.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202104829