Long-term impact of congenital toxoplasmosis on phenotypic and functional features of circulating leukocytes from infants one year after treatment onset

Long-term impact of congenital toxoplasmosis on phenotypic and functional features of circulating leukocytes from infants one year after treatment onset

Copyright © 2021 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 232(2021) vom: 01. Nov., Seite 108859
1. Verfasser: de Araújo, Thádia Evelyn (VerfasserIn)
Weitere Verfasser: Gomes, Angelica Oliveira (BerichterstatterIn), Coelho-Dos-Reis, Jordana Grazziela (BerichterstatterIn), Carneiro, Ana Carolina Aguiar Vasconcelos (BerichterstatterIn), Machado, Anderson Silva (BerichterstatterIn), Andrade, Gláucia Manzan Queiroz, Vasconcelos-Santos, Daniel Vitor, Januário, José Nélio, Peruhype-Magalhães, Vanessa, Teixeira-Carvalho, Andréa, Vitor, Ricardo Wagner Almeida, Antonelli, Lis Ribeiro do Valle, Ferro, Eloisa Amalia Vieira, Martins-Filho, Olindo Assis, UFMG Congenital Toxoplasmosis Brazilian Group - UFMG-CTBG, Machado Azevedo, Danuza O, Machado Carellos, Ericka V, Resende, Luciana Macedo, Castro Romanelli, Roberta M
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Observational Study Research Support, Non-U.S. Gov't Congenital Immune response Infants Phenotypic and functional biomarkers Toxoplasmosis Antiprotozoal Agents Sulfadiazine mehr... 0N7609K889 Pyrimethamine Z3614QOX8W
Beschreibung
Zusammenfassung:Copyright © 2021 Elsevier Inc. All rights reserved.
Changes in immune response of children with congenital toxoplasmosis (CT) regarding infection evolution and therapeutic intervention was addressed. Infants with CT presented increased counts of monocytes, CD3-CD16-CD56High, CD3+CD56+ and CD4+ T-cells 1-year after treatment onset (TOXO1-yearAT). Smaller numbers of CD3-CD16-CD56+ and TCRγδ+ T-cells were specifically observed in infants with retinochoroidal lesions (L(+)). When infants were classified based on the baseline status, expansion of CD3-CD16-CD56High and CD4+ T-cells were observed in L(+) who had active, active/cicatricial or cicatricial lesions. Infants who had active or active/cicatricial lesions display augmented numbers of monocytes, CD3-CD16+CD56+, CD3+CD56+, CD8+DR+ and TCRγδ+ T-cells and those with active/cicatricial or cicatricial at baseline displayed increase in CD14+CD64+ monocytes. Moreover, all L(+) had increased IFN-γ+ and IL-10+ CD4+ T-cells, while L(-) had increased ratios of TNF+, IFN-γ+ and IL-4+ NK-cells upon antigen-specific stimulation. Persistent alterations in leukocytes in TOXO1-yearAT suggest long-term sequels in the immune system of infants with CT
Beschreibung:Date Completed 26.11.2021
Date Revised 26.11.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2021.108859