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|a 10.1016/j.clim.2021.108857
|2 doi
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|a eng
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| 100 |
1 |
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|a Shin, Junghee J
|e verfasserin
|4 aut
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| 245 |
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|a A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 30.11.2021
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|a Date Revised 21.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 Elsevier Inc. All rights reserved.
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|a Aging can alter immunity affecting host defense. COVID-19 has the most devastating clinical outcomes in older adults, raising the implication of immune aging in determining its severity and mortality. We investigated biological predictors for clinical outcomes in a dataset of 13,642 ambulatory and hospitalized adult COVID-19 patients, including younger (age < 65, n = 566) and older (age ≥ 65, n = 717) subjects, with in-depth analyses of inflammatory molecules, cytokines and comorbidities. Disease severity and mortality in younger and older adults were associated with discrete immune mechanisms, including predominant T cell activation in younger adults, as measured by increased soluble IL-2 receptor alpha, and increased IL-10 in older adults although both groups also had shared inflammatory processes, including acute phase reactants, contributing to clinical outcomes. These observations suggest that progression to severe disease and death in COVID-19 may proceed by different immunologic mechanisms in younger versus older subjects and introduce the possibility of age-based immune directed therapies
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Aging
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| 650 |
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|a COVID-19
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| 650 |
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|a Clinical outcome
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| 650 |
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|a Human
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|a Immune
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a Inflammation Mediators
|2 NLM
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| 700 |
1 |
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|a Jeon, Sangchoon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Unlu, Serhan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Par-Young, Jennefer
|e verfasserin
|4 aut
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| 700 |
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|a Shin, Min Sun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kuster, John K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Afinogenova, Yuliya
|e verfasserin
|4 aut
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| 700 |
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|a Kang, Yumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Simonov, Michael
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Buller, Gregory
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bucala, Richard
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kang, Insoo
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 232(2021) vom: 01. Nov., Seite 108857
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|u http://dx.doi.org/10.1016/j.clim.2021.108857
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