Distribution of monocytes subpopulations in the peripheral blood from patients with Behçet's disease - Impact of disease status and colchicine use

Distribution of monocytes subpopulations in the peripheral blood from patients with Behçet's disease - Impact of disease status and colchicine use

Copyright © 2021 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 231(2021) vom: 01. Okt., Seite 108854
1. Verfasser: Gazzito Del Padre, Talita C (VerfasserIn)
Weitere Verfasser: Belem, Joice Moraes F M, de Aguiar, Mariana Freitas, Torquato, Heron Fernandes Vieira, Paredes-Gamero, Edgar Julian, Abdulahad, Wayel H, Brouwer, Elisabeth, de Souza, Alexandre W S
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Behçet syndrome Disease activity Innate immunity Monocytes Systemic vasculitis Tubulin Modulators Colchicine SML2Y3J35T
Beschreibung
Zusammenfassung:Copyright © 2021 Elsevier Inc. All rights reserved.
The innate immune response has a predominant role in Behçet's disease (BD) pathogenesis, but few studies have assessed monocytes in BD. This study aims to evaluate the profile of monocytes subsets in the peripheral blood of BD patients and healthy controls (HC). Monocytes subsets were identified as classical (CD14+CD16-), intermediate (CD14+CD16dim), and non-classical (CD14dimCD16high) subsets. Patients with BD presented a lower number of total monocytes (p = 0.020) and a lower number (p < 0.0001) of circulating classical monocytes than HC. In contrast, the number of intermediate monocytes was higher in BD patients than HC (p < 0.0001). In BD patients, no associations were observed with the severity of clinical manifestations or therapy. Colchicine was associated with a higher number of non-classical monocytes (p = 0.035). In conclusion, BD patients present an altered distribution of monocytes subsets with a reduction of classical and an increase of intermediate subsets
Beschreibung:Date Completed 09.11.2021
Date Revised 09.11.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2021.108854