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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-021-02465-8
|2 doi
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|a pubmed24n1102.xml
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|a (DE-627)NLM330711881
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|a (NLM)34529205
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Wang, Jinhua
|e verfasserin
|4 aut
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|a Cadmium-induced oxidative stress in Meretrix meretrix gills leads to mitochondria-mediated apoptosis
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 23.11.2021
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|a Date Revised 23.11.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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|a Cadmium (Cd) is one of the most important marine environmental pollutants that can cause oxidative damage and apoptosis in living organisms, and mitochondria are the key cell organelles affected by Cd toxicity. In this study, we investigated the effect of Cd on the mitochondria in the gill cells of the clam Meretrix meretrix and the underlying mechanism of mitochondria-mediated apoptosis following exposure to the metal. Exposure of the clams to artificial seawater containing 1.5, 3, 6 and 12 mg L-1 Cd2+ led to swollen mitochondria compared with the untreated clams. The mitochondria also became vacuolated at the higher Cd2+ concentrations. Biochemical assays showed that monoamine oxidase (MAO) activity and mitochondrial membrane potential (Δψm) increased at 1.5 mg L-1 Cd2+, but decreased at higher Cd2+ concentrations, while the activities of malate dehydrogenase (MDH) and cytochrome oxidase (CCO) and the scavenging capacities of anti-superoxide anion (ASA) and anti-hydroxy radical (AHR) all decreased with increasing Cd2+ concentrations. Significant increases in the levels of malondialdehyde (MDA) and H2O2 as well as in the activity levels of caspase-3, -8, and -9 were also observed in the Cd2+-treated clams. The results implied that Cd might induce apoptosis in M. meretrix via the mitochondrial caspase-dependent pathway
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|a Journal Article
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|a Apoptosis
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|a Cadmium
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|a Caspase
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|a Meretrix meretrix
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|a Mitochondrial enzyme
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|a Mitochondrial membrane potential
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 650 |
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|a Cadmium
|2 NLM
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| 650 |
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|a 00BH33GNGH
|2 NLM
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| 650 |
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|a Hydrogen Peroxide
|2 NLM
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| 650 |
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|a BBX060AN9V
|2 NLM
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| 700 |
1 |
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|a Deng, Wanfei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zou, Ting
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bai, Binbin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Alan K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ying, Xueping
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 30(2021), 10 vom: 22. Dez., Seite 2011-2023
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:30
|g year:2021
|g number:10
|g day:22
|g month:12
|g pages:2011-2023
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|u http://dx.doi.org/10.1007/s10646-021-02465-8
|3 Volltext
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