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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202103627
|2 doi
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|a pubmed25n1101.xml
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|a (NLM)34515384
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Zou, Jianhua
|e verfasserin
|4 aut
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| 245 |
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|a Singlet Oxygen "Afterglow" Therapy with NIR-II Fluorescent Molecules
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Improving singlet oxygen (1 O2 ) lifespan by fractionated delivery in dark and hypoxic conditions is a better way to achieve enhanced phototherapeutic efficacy. Herein, three boron dipyrromethene (BODIPY) dyes are synthesized to demonstrate that anthracence-functionalized BODIPY, namely ABDPTPA is an efficient heavy-atom-free photosensitizer for the reversible capture and release of 1 O2 . The spin-orbit charge-transfer intersystem crossing of ABDPTPA promises a high 1 O2 quantum yield of 60% in dichloromethane. Under light irradiation, the anthracene group reacts with 1 O2 to produce endoperoxide. Interestingly, after termination of irradiation, the endoperoxide undergoes thermal cycloreversion to produce 1 O2 , and regenerates the anthracene module to achieve 1 O2 "afterglow," which results in a prolonged half lifetime of 1 O2 for 9.2 min. In vitro cytotoxicity assays indicate that ABDPTPA nanoparticles have a low half-maximal inhibitory concentration (IC50 ) of 3.6 µg mL-1 on U87MG cells. Further, the results of near-infrared-II fluorescence-imaging-guided phototherapy indicate that ABDPTPA nanoparticles can inhibit tumor proliferation even at a low dose (200 µg mL-1 , 100 µL) without any side effects. Therefore, the study provides a generalized 1 O2 "afterglow" strategy to enhance phototheranostics for complete tumor regression
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|a Journal Article
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|a heavy-atom-free photosensitizers
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|a near-infrared-II (NIR-II) imaging
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|a singlet oxygen capture
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|a “afterglow” photodynamic therapy
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|a Singlet Oxygen
|2 NLM
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|a 17778-80-2
|2 NLM
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|a Boron Compounds
|2 NLM
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|a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
|2 NLM
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|a Photosensitizing Agents
|2 NLM
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|a Fluorescent Dyes
|2 NLM
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|a Anthracenes
|2 NLM
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| 700 |
1 |
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|a Li, Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Jianwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xiangchun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Zhen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiaoyuan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 44 vom: 15. Nov., Seite e2103627
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:33
|g year:2021
|g number:44
|g day:15
|g month:11
|g pages:e2103627
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|u http://dx.doi.org/10.1002/adma.202103627
|3 Volltext
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