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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1109/TUFFC.2021.3110083
|2 doi
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|a pubmed24n1596.xml
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|a (DE-627)NLM330208187
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|a (NLM)34478363
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hendricks-Wenger, Alissa
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients
|b A Review
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| 264 |
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|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 10.01.2022
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| 500 |
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|a Date Revised 10.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a New therapeutic strategies are direly needed in the fight against cancer. Over the last decade, several tumor ablation strategies have emerged as stand-alone or combination therapies. Histotripsy is the first completely noninvasive, nonthermal, and nonionizing tumor ablation method. Histotripsy can produce consistent and rapid ablations, even near critical structures. Additional benefits include real-time image guidance, high precision, and the ability to treat tumors of any predetermined size and shape. Unfortunately, the lack of clinically and physiologically relevant preclinical cancer models is often a significant limitation with all focal tumor ablation strategies. The majority of studies testing histotripsy for cancer treatment have focused on small animal models, which have been critical in moving this field forward and will continue to be essential for providing mechanistic insight. While these small animal models have notable translational value, there are significant limitations in terms of scale and anatomical relevance. To address these limitations, a diverse range of large animal models and spontaneous tumor studies in veterinary patients have emerged to complement existing rodent models. These models and veterinary patients are excellent at providing realistic avenues for developing and testing histotripsy devices and techniques designed for future use in human patients. Here, we provide a review of animal models used in preclinical histotripsy studies and compare histotripsy ablation in these models using a series of original case reports across a broad spectrum of preclinical animal models and spontaneous tumors in veterinary patients
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a Arnold, Lauren
|e verfasserin
|4 aut
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|a Gannon, Jessica
|e verfasserin
|4 aut
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|a Simon, Alex
|e verfasserin
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|a Singh, Neha
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|a Sheppard, Hannah
|e verfasserin
|4 aut
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|a Nagai-Singer, Margaret A
|e verfasserin
|4 aut
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|a Imran, Khan Mohammad
|e verfasserin
|4 aut
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|a Lee, Kiho
|e verfasserin
|4 aut
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|a Clark-Deener, Sherrie
|e verfasserin
|4 aut
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|a Byron, Christopher
|e verfasserin
|4 aut
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|a Edwards, Michael R
|e verfasserin
|4 aut
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| 700 |
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|a Larson, Martha M
|e verfasserin
|4 aut
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|a Rossmeisl, John H
|e verfasserin
|4 aut
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|a Coutermarsh-Ott, Sheryl L
|e verfasserin
|4 aut
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|a Eden, Kristin
|e verfasserin
|4 aut
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|a Dervisis, Nikolaos
|e verfasserin
|4 aut
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| 700 |
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|a Klahn, Shawna
|e verfasserin
|4 aut
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|a Tuohy, Joanne
|e verfasserin
|4 aut
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|a Allen, Irving Coy
|e verfasserin
|4 aut
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|a Vlaisavljevich, Eli
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t IEEE transactions on ultrasonics, ferroelectrics, and frequency control
|d 1986
|g 69(2022), 1 vom: 14. Jan., Seite 5-26
|w (DE-627)NLM098181017
|x 1525-8955
|7 nnns
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| 773 |
1 |
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|g volume:69
|g year:2022
|g number:1
|g day:14
|g month:01
|g pages:5-26
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|u http://dx.doi.org/10.1109/TUFFC.2021.3110083
|3 Volltext
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|d 69
|j 2022
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