An Injectable Meta-Biomaterial From Design and Simulation to In Vivo Shaping and Tissue Induction

An Injectable Meta-Biomaterial : From Design and Simulation to In Vivo Shaping and Tissue Induction

© 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 41 vom: 24. Okt., Seite e2102350
1. Verfasser: Béduer, Amélie (VerfasserIn)
Weitere Verfasser: Bonini, Fabien, Verheyen, Connor A, Genta, Martina, Martins, Mariana, Brefie-Guth, Joé, Tratwal, Josefine, Filippova, Aleksandra, Burch, Patrick, Naveiras, Olaia, Braschler, Thomas
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article elastic softening injectable metamaterials shaping tissue reconstruction vascularization Biocompatible Materials Hydrogels
Beschreibung
Zusammenfassung:© 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH.
A novel type of injectable biomaterial with an elastic softening transition is described. The material enables in vivo shaping, followed by induction of 3D stable vascularized tissue. The synthesis of the injectable meta-biomaterial is instructed by extensive numerical simulation as a suspension of irregularly fragmented, highly porous sponge-like microgels. The irregular particle shape dramatically enhances yield strain for in vivo stability against deformation. Porosity of the particles, along with friction between internal surfaces, provides the elastic softening transition. This emergent metamaterial property enables the material to reversibly change stiffness during deformation, allowing native tissue properties to be matched over a wide range of deformation amplitudes. After subcutaneous injection in mice, predetermined shapes can be sculpted manually. The 3D shape is maintained during excellent host tissue integration, with induction of vascular connective tissue that persists to the end of one-year follow-up. The geometrical design is compatible with many hydrogel materials, including cell-adhesion motives for cell transplantation. The injectable meta-biomaterial therefore provides new perspectives in soft tissue engineering and regenerative medicine
Beschreibung:Date Completed 07.02.2022
Date Revised 13.10.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202102350