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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202102489
|2 doi
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|a pubmed25n1098.xml
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|a DE-627
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|a eng
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|a Ruland, André
|e verfasserin
|4 aut
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|a Amphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 07.02.2022
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|a Date Revised 13.10.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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|a Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof-of-concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP-functionalized surfaces
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|a Journal Article
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|a adsorptive surface functionalization
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|a antimicrobial surface properties
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|a cell-instructive properties
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|a styrene-maleic anhydride copolymers
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|a Anti-Infective Agents
|2 NLM
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|a Biocompatible Materials
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|a Cytokines
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|a Glycosaminoglycans
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|a Maleates
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|a Oligopeptides
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|a Polymers
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|a Polyethylene Glycols
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|a 3WJQ0SDW1A
|2 NLM
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|a Styrene
|2 NLM
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|a 44LJ2U959V
|2 NLM
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|a arginyl-glycyl-aspartic acid
|2 NLM
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|a 78VO7F77PN
|2 NLM
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|a maleic acid
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|a 91XW058U2C
|2 NLM
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|a Schenker, Saskia
|e verfasserin
|4 aut
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|a Schirmer, Lucas
|e verfasserin
|4 aut
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|a Friedrichs, Jens
|e verfasserin
|4 aut
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|a Meinhardt, Andrea
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|4 aut
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|a Schwartz, Véronique B
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|a Kaiser, Nadine
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|4 aut
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|a Konradi, Rupert
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|a MacDonald, William
|e verfasserin
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|a Helmecke, Tina
|e verfasserin
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|a Sikosana, Melissa K L N
|e verfasserin
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|a Valtin, Juliane
|e verfasserin
|4 aut
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|a Hahn, Dominik
|e verfasserin
|4 aut
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|a Renner, Lars D
|e verfasserin
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|a Werner, Carsten
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|4 aut
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|a Freudenberg, Uwe
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 42 vom: 01. Okt., Seite e2102489
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:33
|g year:2021
|g number:42
|g day:01
|g month:10
|g pages:e2102489
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|u http://dx.doi.org/10.1002/adma.202102489
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