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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108822
|2 doi
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|a pubmed25n1097.xml
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|a (DE-627)NLM32943957X
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|a (NLM)34400320
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|a (PII)S1521-6616(21)00159-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Xue, Minghui
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Surfactant protein-A inhibits thymic stromal lymphopoietin-mediated T follicular helper cell differentiation and IgE production in asthma
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 09.11.2021
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|a Date Revised 07.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 Elsevier Inc. All rights reserved.
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|a Lung surfactant protein A (SP-A) is critical for immunomodulation. Thymic stromal lymphopoietin (TSLP)-activated dendritic cells (DCs) drive T follicular helper (Tfh) cells differentiation in allergic asthma. We employed wild-type (WT) and SP-A-/- mice injected with TSLP and ovalbumin (OVA)-activated DCs and challenged with OVA. Compared with WT mice, we showed that allergic inflammation was dramatically increased in SP-A-/- mice. In parallel, both IL-4-producing CD45RA-CXCR5+PD-1+CD4+ cells (Tfh2) and IgE were markedly increased in SP-A-/- mice. Further study showed that SP-A prohibited TSLP activated-DCs from expressing OX40L. When we blocked OX40L-OX40 and IL-4R signaling, the differentiation of Tfh2 and IgE responses in SP-A-/- mice was significantly inhibited. In severe asthma patients, SP-A is dysfunctional in modulating the TSLP-DCs-mediated differentiation of Tfh cells. This study suggests that SP-A acts as a modulator of Tfh differentiation and IgE generation in asthma
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Asthma
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| 650 |
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4 |
|a Interleukin (IL)-4
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| 650 |
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4 |
|a Surfactant protein (SP)-A
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| 650 |
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4 |
|a T follicular helper cell (Tfh)
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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|a Pulmonary Surfactant-Associated Protein A
|2 NLM
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| 650 |
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|a Immunoglobulin E
|2 NLM
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| 650 |
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|a 37341-29-0
|2 NLM
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| 650 |
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7 |
|a Thymic Stromal Lymphopoietin
|2 NLM
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| 650 |
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7 |
|a GT0IL38SP4
|2 NLM
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| 700 |
1 |
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|a Xu, Shuqin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Siwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Beiying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ji, Cunpeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nie, Xiaomeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cai, Gang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 231(2021) vom: 15. Okt., Seite 108822
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:231
|g year:2021
|g day:15
|g month:10
|g pages:108822
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2021.108822
|3 Volltext
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