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|a 10.1002/adma.202101467
|2 doi
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|a pubmed24n1094.xml
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|a DE-627
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|e rakwb
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|a eng
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|a Liang, Shuang
|e verfasserin
|4 aut
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|a A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 18.01.2022
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|a Date Revised 18.01.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a The development and optimization of sonosensitizers for elevating intratumoral reactive oxygen species (ROS) are definitely appealing in current sonodynamic therapy (SDT). Given this, branched vanadium tetrasulfide (VS4 ) nanodendrites with a narrower bandgap (compared with the most extensively explored sonosensitizers) are presented as a new source of sonosensitizer, which allows a more effortless separation of sono-triggered electron-hole pairs for ROS generation. Specifically, platinum (Pt) nanoparticles and endogenous high levels of glutathione (GSH) are rationally engineered to further optimize its sono-sensitized performance. As cocatalyst, Pt is conducive to trapping electrons, whereas GSH, as a natural hole-scavenger, tends to capture holes. Compared with the pristine VS4 sonosensitizer, the GSH-Pt-VS4 nanocomposite can greatly prolong the lifetime of the charge and confer a highly efficacious ROS production activity. Furthermore, such nanoplatforms are capable of reshaping tumor microenvironments to realize ROS overproduction, contributed by overcoming tumor hypoxia to improve SDT-triggered singlet oxygen production, catalyzing endogenic hydrogen peroxide into destructive hydroxyl radicals for chemodynamic therapy, and depleting GSH to amplify intratumoral oxidative stress. All these combined effects result in a significantly efficient tumor suppression outcome. This study enriches sonosensitizer research and proves that sonosensitizers can be rationally optimized by charge separation engineering strategy
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|a Journal Article
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|a cocatalysts
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|a hole-scavengers
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|a sonodynamic therapy
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|a sonosensitizers
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|a vanadium tetrasulfide
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|a Free Radicals
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Sulfides
|2 NLM
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|a Vanadium Compounds
|2 NLM
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|a Platinum
|2 NLM
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|a 49DFR088MY
|2 NLM
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|a Glutathione
|2 NLM
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| 650 |
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|a GAN16C9B8O
|2 NLM
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| 700 |
1 |
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|a Liu, Bin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiao, Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yuan, Meng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Ping'an
|e verfasserin
|4 aut
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| 700 |
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|a Cheng, Ziyong
|e verfasserin
|4 aut
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| 700 |
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|a Lin, Jun
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 36 vom: 16. Sept., Seite e2101467
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:33
|g year:2021
|g number:36
|g day:16
|g month:09
|g pages:e2101467
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|u http://dx.doi.org/10.1002/adma.202101467
|3 Volltext
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