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20231227130537.0 |
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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.13484
|2 doi
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|a pubmed24n1224.xml
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|a (DE-627)NLM327831294
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|a (NLM)34237181
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Rehman, Saima
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Zebrafish intestinal transcriptome highlights subdued inflammatory responses to dietary soya bean and efficacy of yeast β-glucan
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 12.11.2021
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 The Authors. Journal of Fish Diseases published by John Wiley & Sons Ltd.
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|a Anti-nutritional factors in dietary components can have a negative impact on the intestinal barrier. Here, we present soya bean-induced changes in the intestine of juvenile zebrafish and the effect of yeast β-glucan through a transcriptomic approach. The inclusion of soya bean meal affected the expression of several intestinal barrier function-related genes like arl4ca, rab25b, rhoub, muc5ac, muc5d, clcn2c and cltb in zebrafish. Several metabolic genes like cyp2x10.2, cyp2aa2, aldh3a2b, crata, elovl4, elovl6, slc51a, gpat2 and ATP-dependent peptidase activity (lonrf, clpxb) were altered in the intestinal tissue. The expression of immune-related genes like nlrc3, nlrp12, gimap8, prdm1 and tph1a, and genes related to cell cycle, DNA damage and DNA repair (e.g. spo11, rad21l1, nabp1b, spata22, tdrd9) were also affected in the soya bean fed group. Furthermore, our study suggests the plausible effect of yeast β-glucan through the modulation of several genes that regulate immune responses and barrier integrity. Our findings indicate a subdued inflammation in juvenile zebrafish fed soya bean meal and the efficacy of β-glucan to counter these subtle inflammatory responses
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|a Journal Article
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|a intestinal barrier
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|a small GTPase
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|a soya bean meal
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|a yeast β-glucan
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|a zebrafish
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| 650 |
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|a Polysaccharides
|2 NLM
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| 700 |
1 |
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|a Gora, Adnan H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Siriyappagouder, Prabhugouda
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brugman, Sylvia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fernandes, Jorge M O
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dias, Jorge
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kiron, Viswanath
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 44(2021), 10 vom: 01. Okt., Seite 1619-1637
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnns
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| 773 |
1 |
8 |
|g volume:44
|g year:2021
|g number:10
|g day:01
|g month:10
|g pages:1619-1637
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| 856 |
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|u http://dx.doi.org/10.1111/jfd.13484
|3 Volltext
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