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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202008793
|2 doi
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|a pubmed24n1092.xml
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|a (DE-627)NLM327817763
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|a (NLM)34235789
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|e rakwb
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|a eng
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|a Kim, Taejeong
|e verfasserin
|4 aut
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|a Polymeric Aggregate-Embodied Hybrid Nitric-Oxide-Scavenging and Sequential Drug-Releasing Hydrogel for Combinatorial Treatment of Rheumatoid Arthritis
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 18.01.2022
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|a Date Revised 18.01.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Selective depletion of overproduced nitric oxide (NO) with nanoscavengers is a promising approach for treating rheumatoid arthritis (RA), preventing both oxidative/nitrosative stress and the upregulation of immune cells. However, its practical applications are limited owing to the minimum time interval between intra-articular injections and unwanted off-target NO depletion. Herein, the rational design of an injectable in situ polymeric aggregate-embodied hybrid NO-scavenging and sequential drug-releasing (M-NO) gel platform for the combinatorial treatment of RA by incorporating a "clickable" NO-cleavable cross-linker (DA-NOCCL) is reported. This network is held together with polymeric aggregates to achieve a self-healing capability for visco-supplementation and on-demand dual drug (both hydrophilic and hydrophobic)-releasing properties, depending on the NO concentration. Moreover, consecutive NO-scavenging action reduces pro-inflammatory cytokine levels in lipopolysaccharides-stimulated macrophage cell lines in vitro. Finally, the intra-articularly injected M-NO gel with anti-inflammatory dexamethasone significantly alleviates the symptoms of RA, with negligible toxicity, in animal models. It is believed that this novel M-NO gel platform will provide a guideline for the combinatorial treatment of RA and various NO-related diseases
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|a Journal Article
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|a hydrogels
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|a nitric oxide
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|a rheumatoid arthritis
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|a stimuli-responsive materials
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|a Anti-Inflammatory Agents
|2 NLM
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|a Azides
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|a Delayed-Action Preparations
|2 NLM
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|a Drug Carriers
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|a Hydrogels
|2 NLM
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|a Lipopolysaccharides
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|a Polymers
|2 NLM
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|a Nitric Oxide
|2 NLM
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|a 31C4KY9ESH
|2 NLM
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|a Collagen
|2 NLM
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|a 9007-34-5
|2 NLM
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| 700 |
1 |
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|a Suh, Jeeyeon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Won Jong
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 34 vom: 08. Aug., Seite e2008793
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:33
|g year:2021
|g number:34
|g day:08
|g month:08
|g pages:e2008793
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|u http://dx.doi.org/10.1002/adma.202008793
|3 Volltext
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