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20231225201437.0 |
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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.13472
|2 doi
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|a pubmed24n1092.xml
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|a (DE-627)NLM327736062
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|a (NLM)34227114
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Sun, Zhong-Chen
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Evaluation of the antiviral activity of naringenin, a major constituent of Typha angustifolia, against white spot syndrome virus in crayfish Procambarus clarkii
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 12.11.2021
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|a Date Revised 12.11.2021
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|a published: Print-Electronic
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|a RefSeq: KT995472.1, EU254488.3, KC333178.1, KM068092.1, HQ414581.1, DQ301506.1, KX268742.1, AF437613.1, KX444578.1
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|a Citation Status MEDLINE
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| 520 |
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|a © 2021 John Wiley & Sons Ltd.
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|a White spot syndrome virus (WSSV) is a serious pathogen threatening global crustacean aquaculture with no commercially available drugs. Herbal medicines widely used in antiviral research offer a rich reserve for drug discovery. Here, we investigated the inhibitory activity of 13 herbal medicines against WSSV in crayfish Procambarus clarkii and discovered that naringenin (NAR) has potent anti-WSSV activity. In the preliminary screening, the extracts of Typha angustifolia displayed the highest inhibitory activity on WSSV replication (84.62%, 100 mg/kg). Further, NAR, the main active compound of T. angustifolia, showed a much higher inhibition rate (92.85%, 50 mg/kg). NAR repressed WSSV proliferation followed a dose-dependent manner and significantly improved the survival of WSSV-challenged crayfish. Moreover, pre- or post-treatment of NAR displayed a comparable inhibition on the viral loads. NAR decreased the transcriptional levels of vital genes in viral life cycle, particularly for the immediately early-stage gene ie1. Further results showed that NAR could decrease the STAT gene expression to block ie1 transcription. Besides, NAR modulated immune-related gene Hsp70, antioxidant (cMnSOD, mMnSOD, CAT, GST), anti-inflammatory (COX-1, COX-2) and pro-apoptosis-related factors (Bax and BI-1) to inhibit WSSV replication. Overall, these results suggest that NAR may have the potential to be developed as preventive or therapeutic agent against WSSV
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Procambarus clarkii
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| 650 |
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4 |
|a Naringenin
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| 650 |
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4 |
|a anti-oxidative
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| 650 |
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4 |
|a apoptosis
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| 650 |
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4 |
|a herbal medicines
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| 650 |
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4 |
|a white spot syndrome virus
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| 650 |
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7 |
|a Antiviral Agents
|2 NLM
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| 650 |
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7 |
|a Flavanones
|2 NLM
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| 650 |
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7 |
|a naringenin
|2 NLM
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| 650 |
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7 |
|a HN5425SBF2
|2 NLM
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| 700 |
1 |
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|a Chen, Cheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Fei-Fan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Bing-Ke
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Jing-Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Hai-Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Gao-Xue
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 44(2021), 10 vom: 06. Okt., Seite 1503-1513
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnns
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| 773 |
1 |
8 |
|g volume:44
|g year:2021
|g number:10
|g day:06
|g month:10
|g pages:1503-1513
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/jfd.13472
|3 Volltext
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|d 44
|j 2021
|e 10
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|c 10
|h 1503-1513
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