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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erab252
|2 doi
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|a pubmed24n1091.xml
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|a (DE-627)NLM327425857
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|a (NLM)34195821
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Zhou, Yang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Double-faced role of Bcl-2-associated athanogene 7 in plant-Phytophthora interaction
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| 264 |
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 09.08.2021
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|a Date Revised 09.08.2021
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a Due to their sessile nature, plants must respond to various environmental assaults in a coordinated manner. The endoplasmic reticulum is a central hub for plant responses to various stresses. We previously showed that Phytophthora utilizes effector PsAvh262-mediated binding immunoglobulin protein (BiP) accumulation for suppressing endoplasmic reticulum stress-triggered cell death. As a BiP binding partner, Bcl-2-associated athanogene 7 (BAG7) plays a crucial role in the maintenance of the unfolded protein response, but little is known about its role in plant immunity. In this work, we reveal a double-faced role of BAG7 in Arabidopsis-Phytophthora interaction in which it regulates endoplasmic reticulum stress-mediated immunity oppositely in different cellular compartments. In detail, it acts as a susceptibility factor in the endoplasmic reticulum, but plays a resistance role in the nucleus against Phytophthora. Phytophthora infection triggers the endoplasmic reticulum-to-nucleus translocation of BAG7, the same as abiotic heat stress; however, this process can be prevented by PsAvh262-mediated BiP accumulation. Moreover, the immunoglobulin/albumin-binding domain in PsAvh262 is essential for both pathogen virulence and BiP accumulation. Taken together, our study uncovers a double-faced role of BAG7; Phytophthora advances its colonization in planta by utilizing an effector to detain BAG7 in the endoplasmic reticulum
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a BAG7
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|a BiP
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|a ER stress-mediated immunity
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|a effector
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4 |
|a plant–Phytophthora interaction
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|a susceptibility factor
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| 650 |
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|a Arabidopsis Proteins
|2 NLM
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| 700 |
1 |
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|a Yang, Kun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yurong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ai, Gan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bai, Tian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Ruofei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Duan, Weiwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Peng, Hao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xiaobo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xia, Ai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yuanchao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jing, Maofeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dou, Daolong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dickman, Marty B
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 72(2021), 15 vom: 28. Juli, Seite 5751-5765
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:72
|g year:2021
|g number:15
|g day:28
|g month:07
|g pages:5751-5765
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|u http://dx.doi.org/10.1093/jxb/erab252
|3 Volltext
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|d 72
|j 2021
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|h 5751-5765
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