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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202101155
|2 doi
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|a pubmed24n1481.xml
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|a DE-627
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|a eng
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|a Song, Rundi
|e verfasserin
|4 aut
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|a Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Immunotherapy shows promising therapeutic potential for long-term tumor regression. However, current cancer immunotherapy displays a low response rate due to insufficient immunogenicity of the tumor cells. To address these challenges, herein, intracellular-acidity-activatable dynamic nanoparticles for eliciting immunogenicity by inducing ferroptosis of the tumor cells are engineered. The nanoparticles are engineered by integrating an ionizable block copolymer and acid-liable phenylboronate ester (PBE) dynamic covalent bonds for tumor-specific delivery of the ferroptosis inducer, a glutathione peroxidase 4 inhibitor RSL-3. The nanoparticles can stably encapsulate RSL-3 inside the hydrophobic core via π-π stacking interaction with the PBE groups at neutral pH (pH = 7.4), while releasing the payload in the endocytic vesicles (pH = 5.8-6.2) by acidity-triggered cleavage of the PBE dynamic covalent bonds. Furthermore, the nanoparticles can perform acid-activatable photodynamic therapy by protonation of the ionizable core, and significantly recruit tumor-infiltrating T lymphocytes for interferon gamma secretion, and thus sensitize the tumor cells to RSL-3-inducible ferroptosis. The combination of nanoparticle-induced ferroptosis and blockade of programmed death ligand 1 efficiently inhibits growth of B16-F10 melanoma tumor and lung metastasis of 4T1 breast tumors, suggesting the promising potential of ferroptosis induction for promoting cancer immunotherapy
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|a Journal Article
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|a T lymphocytes
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|a cancer immunotherapy
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|a ferroptosis
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|a immune resistance
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|a immunogenic cell death
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1 |
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|a Li, Tianliang
|e verfasserin
|4 aut
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1 |
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|a Ye, Jiayi
|e verfasserin
|4 aut
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1 |
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|a Sun, Fang
|e verfasserin
|4 aut
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1 |
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|a Hou, Bo
|e verfasserin
|4 aut
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1 |
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|a Saeed, Madiha
|e verfasserin
|4 aut
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1 |
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|a Gao, Jing
|e verfasserin
|4 aut
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1 |
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|a Wang, Yingjie
|e verfasserin
|4 aut
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1 |
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|a Zhu, Qiwen
|e verfasserin
|4 aut
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1 |
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|a Xu, Zhiai
|e verfasserin
|4 aut
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|a Yu, Haijun
|e verfasserin
|4 aut
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 31 vom: 20. Aug., Seite e2101155
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:33
|g year:2021
|g number:31
|g day:20
|g month:08
|g pages:e2101155
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|u http://dx.doi.org/10.1002/adma.202101155
|3 Volltext
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