Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

© 2021 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 31 vom: 20. Aug., Seite e2101155
1. Verfasser: Song, Rundi (VerfasserIn)
Weitere Verfasser: Li, Tianliang, Ye, Jiayi, Sun, Fang, Hou, Bo, Saeed, Madiha, Gao, Jing, Wang, Yingjie, Zhu, Qiwen, Xu, Zhiai, Yu, Haijun
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article T lymphocytes cancer immunotherapy ferroptosis immune resistance immunogenic cell death
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520 |a Immunotherapy shows promising therapeutic potential for long-term tumor regression. However, current cancer immunotherapy displays a low response rate due to insufficient immunogenicity of the tumor cells. To address these challenges, herein, intracellular-acidity-activatable dynamic nanoparticles for eliciting immunogenicity by inducing ferroptosis of the tumor cells are engineered. The nanoparticles are engineered by integrating an ionizable block copolymer and acid-liable phenylboronate ester (PBE) dynamic covalent bonds for tumor-specific delivery of the ferroptosis inducer, a glutathione peroxidase 4 inhibitor RSL-3. The nanoparticles can stably encapsulate RSL-3 inside the hydrophobic core via π-π stacking interaction with the PBE groups at neutral pH (pH = 7.4), while releasing the payload in the endocytic vesicles (pH = 5.8-6.2) by acidity-triggered cleavage of the PBE dynamic covalent bonds. Furthermore, the nanoparticles can perform acid-activatable photodynamic therapy by protonation of the ionizable core, and significantly recruit tumor-infiltrating T lymphocytes for interferon gamma secretion, and thus sensitize the tumor cells to RSL-3-inducible ferroptosis. The combination of nanoparticle-induced ferroptosis and blockade of programmed death ligand 1 efficiently inhibits growth of B16-F10 melanoma tumor and lung metastasis of 4T1 breast tumors, suggesting the promising potential of ferroptosis induction for promoting cancer immunotherapy 
650 4 |a Journal Article 
650 4 |a T lymphocytes 
650 4 |a cancer immunotherapy 
650 4 |a ferroptosis 
650 4 |a immune resistance 
650 4 |a immunogenic cell death 
700 1 |a Li, Tianliang  |e verfasserin  |4 aut 
700 1 |a Ye, Jiayi  |e verfasserin  |4 aut 
700 1 |a Sun, Fang  |e verfasserin  |4 aut 
700 1 |a Hou, Bo  |e verfasserin  |4 aut 
700 1 |a Saeed, Madiha  |e verfasserin  |4 aut 
700 1 |a Gao, Jing  |e verfasserin  |4 aut 
700 1 |a Wang, Yingjie  |e verfasserin  |4 aut 
700 1 |a Zhu, Qiwen  |e verfasserin  |4 aut 
700 1 |a Xu, Zhiai  |e verfasserin  |4 aut 
700 1 |a Yu, Haijun  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 33(2021), 31 vom: 20. Aug., Seite e2101155  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:33  |g year:2021  |g number:31  |g day:20  |g month:08  |g pages:e2101155 
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