Facile Synthesis of the Cu, N-CDsGO-CS Hydrogel with Enhanced Antibacterial Activity for Effective Treatment of Wound Infection
Drug resistance and increasing dangers during antibiotic treatment have brought a new eternal task for the research of effective antibacterial agents or therapeutics. In this work, we used Cu, N-doped carbon dots (Cu, N-CDs) to modify graphene oxide (GO) nanosheets and then loaded to chitosan (CS) h...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 37(2021), 26 vom: 06. Juli, Seite 7928-7935 |
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| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2021
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Anti-Bacterial Agents Hydrogels graphene oxide Graphite 7782-42-5 Chitosan 9012-76-4 |
| Zusammenfassung: | Drug resistance and increasing dangers during antibiotic treatment have brought a new eternal task for the research of effective antibacterial agents or therapeutics. In this work, we used Cu, N-doped carbon dots (Cu, N-CDs) to modify graphene oxide (GO) nanosheets and then loaded to chitosan (CS) hydrogels via electrostatic interaction to form Cu, N-CDsGO-CS hydrogel nanoplatforms to treat Staphylococcus aureus and Escherichia coli. The excellent antibacterial activity is from the combined effects of hyperthermia and reactive oxygen species generated under near-infrared (NIR) laser irradiation of the Cu, N-CDs@GO-CS hydrogel, which shows excellent antibacterial activity compared with the CS hydrogel or the Cu, N-CDs@GO-CS hydrogel without NIR laser irradiation. Moreover, the inherent antibacterial nature of the CS hydrogel or the Cu, N-CDs@GO-CS hydrogel was used to treat bacteria-infected wounds in mice, which also protected the wound area from second infection. In vivo experiments demonstrate favorable wound healing results and have no significant harmful side effects to the major organs in mice. Overall, this work demonstrates that the antibacterial Cu, N-CDs@GO-CS hydrogel offers significant prospect as an antibacterial reagent for wound healing |
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| Beschreibung: | Date Completed 12.07.2021 Date Revised 12.07.2021 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/acs.langmuir.1c00529 |