A Phytophthora capsici RXLR effector targets and inhibits the central immune kinases to suppress plant immunity

A Phytophthora capsici RXLR effector targets and inhibits the central immune kinases to suppress plant immunity

© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 232(2021), 1 vom: 21. Okt., Seite 264-278
1. Verfasser: Liang, Xiangxiu (VerfasserIn)
Weitere Verfasser: Bao, Yazhou, Zhang, Meixiang, Du, Dandan, Rao, Shaofei, Li, Yixin, Wang, Xiaodan, Xu, Guangyuan, Zhou, Zhaoyang, Shen, Danyu, Chang, Qin, Duan, Weiwei, Ai, Gan, Lu, Jie, Zhou, Jian-Min, Dou, Daolong
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Phytophthora capsici RLCK-VII RXLR25 immune kinases plant immunity Arabidopsis Proteins BIK1 protein, Arabidopsis EC 2.7.11.1 Protein Serine-Threonine Kinases
Beschreibung
Zusammenfassung:© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation.
Receptor-like cytoplasmic kinase subfamily VII (RLCK-VII) proteins are the central immune kinases in plant pattern-recognition receptor (PRR) complexes, and they orchestrate a complex array of defense responses against bacterial and fungal pathogens. However, the role of RLCK-VII in plant-oomycete pathogen interactions has not been established. Phytophthora capsici is a notorious oomycete pathogen that infects many agriculturally important vegetables. Here, we report the identification of RXLR25, an RXLR effector that is required for the virulence of P. capsici. In planta expression of RXLR25 significantly enhanced plants' susceptibility to Phytophthora pathogens. Microbial pattern-induced immune activation in Arabidopsis was severely impaired by RXLR25. We further showed that RXLR25 interacts with RLCK-VII proteins. Using nine rlck-vii high-order mutants, we observed that RLCK-VII-6 and RLCK-VII-8 members are required for resistance to P. capsici. The RLCK-VII-6 members are specifically required for Phytophthora culture filtrate (CF)-induced immune responses. RXLR25 directly targets RLCK-VII proteins such as BIK1, PBL8, and PBL17 and inhibits pattern-induced phosphorylation of RLCK-VIIs to suppress downstream immune responses. This study identified a key virulence factor for P. capsici, and the results revealed the importance of RLCK-VII proteins in plant-oomycete interactions
Beschreibung:Date Completed 09.09.2021
Date Revised 04.12.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1469-8137
DOI:10.1111/nph.17573