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DE-627 |
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20231225195242.0 |
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cr uuu---uuuuu |
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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108784
|2 doi
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|a pubmed24n1089.xml
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|a (DE-627)NLM326740937
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|a (NLM)34126239
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|a (PII)S1521-6616(21)00121-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a von Kaeppler, Ericka P
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Interleukin 4 promotes anti-inflammatory macrophages that clear cartilage debris and inhibits osteoclast development to protect against osteoarthritis
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| 264 |
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1 |
|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 16.09.2021
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|a Date Revised 16.09.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 Elsevier Inc. All rights reserved.
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|a OBJECTIVE: Osteoarthritis (OA), the leading cause of joint failure, is characterized by breakdown of articular cartilage and remodeling of subchondral bone in synovial joints. Despite the high prevalence and debilitating effects of OA, no disease-modifying drugs exist. Increasing evidence, including genetic variants of the interleukin 4 (IL-4) and IL-4 receptor genes, implicates a role for IL-4 in OA, however, the mechanism underlying IL-4 function in OA remains unknown. Here, we investigated the role of IL-4 in OA pathogenesis
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| 520 |
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|a METHODS: Il4-, myeloid-specific-Il4ra-, and Stat6-deficient and control mice were subjected to destabilization of the medial meniscus to induce OA. Macrophages, osteoclasts, and synovial explants were stimulated with IL-4 in vitro, and their function and expression profiles characterized
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| 520 |
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|a RESULTS: Mice lacking IL-4, IL-4Ra in myeloid cells, or STAT6 developed exacerbated cartilage damage and osteophyte formation relative to WT controls. In vitro analyses revealed that IL-4 downregulates osteoarthritis-associated genes, enhances macrophage phagocytosis of cartilage debris, and inhibits osteoclast differentiation and activation via the type I receptor
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| 520 |
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|a CONCLUSION: Our findings demonstrate that IL-4 protects against osteoarthritis in a myeloid and STAT6-dependent manner. Further, IL-4 can promote an immunomodulatory microenvironment in which joint-resident macrophages polarize towards an M2 phenotype and efficiently clear pro-inflammatory debris, and osteoclasts maintain a homeostatic level of activity in subchondral bone. These findings support a role for IL-4 modulation of myeloid cell types in maintenance of joint health and identify a pathway that could provide therapeutic benefit for osteoarthritis
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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4 |
|a Inerleukin-4
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| 650 |
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4 |
|a Inflammation
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| 650 |
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4 |
|a Macrophage
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| 650 |
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4 |
|a Myeloid
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| 650 |
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4 |
|a Osteoarthritis
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| 650 |
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4 |
|a Osteoclast
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| 650 |
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7 |
|a IL4 protein, human
|2 NLM
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| 650 |
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7 |
|a Il4 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Il4ra protein, mouse
|2 NLM
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| 650 |
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7 |
|a Receptors, Cell Surface
|2 NLM
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| 650 |
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7 |
|a STAT6 Transcription Factor
|2 NLM
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| 650 |
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7 |
|a Stat6 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Interleukin-4
|2 NLM
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| 650 |
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7 |
|a 207137-56-2
|2 NLM
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| 700 |
1 |
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|a Wang, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Raghu, Harini
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bloom, Michelle S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wong, Heidi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Robinson, William H
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 229(2021) vom: 11. Aug., Seite 108784
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:229
|g year:2021
|g day:11
|g month:08
|g pages:108784
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2021.108784
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 229
|j 2021
|b 11
|c 08
|h 108784
|