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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108773
|2 doi
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|a pubmed24n1088.xml
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|a (DE-627)NLM326504303
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|a (NLM)34102315
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|a (PII)S1521-6616(21)00110-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhang, Lu-Xue
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Dynamics of HIV reservoir decay and naïve CD4 T-cell recovery between immune non-responders and complete responders on long-term antiretroviral treatment
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 16.09.2021
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|a Date Revised 16.09.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021. Published by Elsevier Inc.
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|a BACKGROUND: The dynamics of viral reservoir decay and naïve CD4 T-cell recovery between immunological non-responders (INR) and complete responders (CR) during long-term antiretroviral treatment (ART) are not fully known
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| 520 |
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|a METHODS: Twenty-eight chronic HIV-infected individuals on 5-year ART were divided into two groups: INR (CD4 counts ≤350 cells/μL, n = 13) and CR (CD4 counts ≥500 cells/μL, n = 15). The levels of HIV DNA and cell-associated HIV RNA (CA-RNA), CD4 counts, naïve CD4 counts and their correlations were analyzed at baseline, years 1, 3 and 5 of ART between the two groups. Expression of PD-1 on CD4 T-cells was quantified by flow cytometry. Linear mixed effect models were used to estimate the change procession in repeated measurements over 5 years. Slopes of the above-mentioned indicators were estimated using participant-specific linear regressions, respectively
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| 520 |
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|a RESULTS: INR maintained higher levels of HIV DNA and CA-RNA with higher percentages of PD-1+CD4 T-cells compared with CR during 5-year ART, concurrent with lower naïve CD4 T-cells. However, the rates of HIV DNA and CA-RNA decay in INR were not different from that in CR over time, and INR had higher rates of naïve CD4 T-cell percentage recovery. The baseline levels of HIV DNA were positively associated with the 5-year levels of HIV DNA, but negatively associated with the 5-year naïve CD4 counts
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| 520 |
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|a CONCLUSIONS: INR maintained significantly higher viral reservoir and lower naïve CD4 T-cells compared with CR during 5-year ART, however, the rates of reservoir decay and naïve CD4 T-cell percentage growth within INR were not lower than that in CR over time
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4 |
|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a HIV
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| 650 |
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4 |
|a HIV reservoir
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| 650 |
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|a Immunological non-responders
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| 650 |
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|a Long-term antiretroviral therapy
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| 650 |
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4 |
|a naïve CD4 T-cell recovery
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| 650 |
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7 |
|a DNA, Viral
|2 NLM
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| 650 |
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7 |
|a RNA, Viral
|2 NLM
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| 700 |
1 |
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|a Song, Jin-Wen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Chao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fan, Xing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Hui-Huang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Ruo-Nan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Jia-Ye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Ji-Yuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Li-Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Chun-Bao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jin, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Fu-Sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiao, Yan-Mei
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 229(2021) vom: 01. Aug., Seite 108773
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:229
|g year:2021
|g day:01
|g month:08
|g pages:108773
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2021.108773
|3 Volltext
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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|d 229
|j 2021
|b 01
|c 08
|h 108773
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