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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202101095
|2 doi
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|a pubmed25n1087.xml
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|a eng
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|a Du, Fangxue
|e verfasserin
|4 aut
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|a Pd-Single-Atom Coordinated Biocatalysts for Chem-/Sono-/Photo-Trimodal Tumor Therapies
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a The diversity, complexity, and heterogeneity of malignant tumor seriously undermine the efficiency of mono-modal treatment. Recently, multi-modal therapeutics with enhanced antitumor efficiencies have attracted increasing attention. However, designing a nanotherapeutic platform with uniform morphology in nanoscale that integrates with efficient chem-/sono-/photo-trimodal tumor therapies is still a great challenge. Here, new and facile Pd-single-atom coordinated porphyrin-based polymeric networks as biocatalysts, namely, Pd-Pta/Por, for chem-/sono-/photo-trimodal tumor therapies are designed. The atomic morphology and chemical structure analysis prove that the biocatalyst consists of atomic Pd-N coordination networks with a Pd-N2 -Cl2 catalytic center. The characterization of peroxidase-like catalytic activities displays that the Pd-Pta/Por can generate abundant •OH radicals for chemodynamic therapies. The ultrasound irradiation or laser excitation can significantly boost the catalytic production of 1 O2 by the porphyrin-based sono-/photosensitizers to achieve combined sono-/photodynamic therapies. The superior catalytic production of •OH is further verified by density functional theory calculation. Finally, the corresponding in vitro and in vivo experiments have demonstrated their synergistic chem-/sono-/photo-trimodal antitumor efficacies. It is believed that this study provides new promising single-atom-coordinated polymeric networks with highly efficient biocatalytic sites and synergistic trimodal therapeutic effects, which may inspire many new findings in reactive oxygen species-related biological applications across broad therapeutics and biomedical fields
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|a Journal Article
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|a catalytic ROS generation
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|a nanomedicines
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|a porphyrin-based coordination polymer
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|a single-atom biocatalysts
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|a trimodal tumor therapy
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|a Palladium
|2 NLM
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|a 5TWQ1V240M
|2 NLM
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|a Porphyrins
|2 NLM
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|a Photosensitizing Agents
|2 NLM
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|a Antineoplastic Agents
|2 NLM
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|a Singlet Oxygen
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|a 17778-80-2
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|a Hydroxyl Radical
|2 NLM
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|a 3352-57-6
|2 NLM
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| 700 |
1 |
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|a Liu, Luchang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Zihe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Zhenyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Geng, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Bihui
|e verfasserin
|4 aut
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|a Ma, Tian
|e verfasserin
|4 aut
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|a Xiang, Xi
|e verfasserin
|4 aut
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| 700 |
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|a Ma, Lang
|e verfasserin
|4 aut
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| 700 |
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|a Cheng, Chong
|e verfasserin
|4 aut
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| 700 |
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|a Qiu, Li
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 29 vom: 15. Juli, Seite e2101095
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:33
|g year:2021
|g number:29
|g day:15
|g month:07
|g pages:e2101095
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|u http://dx.doi.org/10.1002/adma.202101095
|3 Volltext
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