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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108764
|2 doi
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|a pubmed24n1087.xml
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|a (DE-627)NLM32638099X
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|a (NLM)34089860
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|a (PII)S1521-6616(21)00101-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhuang, Haoyang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 16.09.2021
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|a Date Revised 03.11.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021. Published by Elsevier Inc.
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|a C57BL/6 mice with pristane-induced lupus develop macrophage-dependent diffuse alveolar hemorrhage (DAH), which is blocked by treatment with liver X receptor (LXR) agonists and is exacerbated by low IL-10 levels. Serp-1, a myxomavirus-encoded serpin that impairs macrophage activation and plasminogen activation, blocks DAH caused by MHV68 infection. We investigated whether Serp-1 also could block DAH in pristane-induced lupus. Pristane-induced DAH was prevented by treatment with recombinant Serp-1 and macrophages from Serp1-treated mice exhibited an anti-inflammatory M2-like phenotype. Therapy activated LXR, promoting M2 polarization and expression of Kruppel-like factor-4 (KLH4), which upregulates IL-10. In contrast, deficiency of tissue plasminogen activator or plasminogen activator inhibitor had little effect on DAH. We conclude that Serp-1 blocks pristane-induced lung hemorrhage by enhancing LXR-regulated M2 macrophage polarization and KLH4-regulated IL-10 production. In view of the similarities between DAH in pristane-treated mice and SLE patients, Serp-1 may represent a potential new therapy for this severe complication of SLE
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Diffuse alveolar hemorrhage
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| 650 |
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|a Liver X receptors
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| 650 |
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|a Macrophages
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| 650 |
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|a Myxomavirus
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|a SLE
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|a Serpin
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|a IL10 protein, mouse
|2 NLM
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|a Klf4 protein, mouse
|2 NLM
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| 650 |
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|a Kruppel-Like Factor 4
|2 NLM
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| 650 |
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|a Liver X Receptors
|2 NLM
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| 650 |
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|a Nr1h3 protein, mouse
|2 NLM
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| 650 |
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|a Serpins
|2 NLM
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| 650 |
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|a Terpenes
|2 NLM
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| 650 |
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|a Viral Proteins
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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|a 130068-27-8
|2 NLM
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| 650 |
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|a pristane
|2 NLM
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| 650 |
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7 |
|a 26HZV48DT1
|2 NLM
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| 700 |
1 |
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|a Han, Shuhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Reeves, Westley H
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 229(2021) vom: 15. Aug., Seite 108764
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:229
|g year:2021
|g day:15
|g month:08
|g pages:108764
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|u http://dx.doi.org/10.1016/j.clim.2021.108764
|3 Volltext
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