Predicting an optimal composite outcome variable for Huntington's disease clinical trials
While there is no known cure for Huntington's disease (HD), there are early-phase clinical trials aimed at altering disease progression patterns. There is, however, no obvious single outcome for these trials to evaluate treatment efficacy. Currently used outcomes are, while reasonable, not opti...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Journal of applied statistics. - 1991. - 48(2021), 7 vom: 15., Seite 1339-1348
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| 1. Verfasser: |
Sewell, Daniel K
(VerfasserIn) |
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| Weitere Verfasser: |
Penney, Journey,
Jay, Melissa,
Zhang, Ying,
Paulsen, Jane S |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2021
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| Zugriff auf das übergeordnete Werk: | Journal of applied statistics
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| Schlagworte: | Journal Article
longitudinal data
mixed effects models
optimization
signal-to-noise ratio
translational science |
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