A Signature Enrichment Design with Bayesian Adaptive Randomization
Clinical trials in the era of precision cancer medicine aim to identify and validate biomarker signatures which can guide the assignment of individually optimal treatments to patients. In this article, we propose a group sequential randomized phase II design, which updates the biomarker signature as...
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Détails bibliographiques
| Publié dans: | Journal of applied statistics. - 1991. - 48(2021), 6 vom: 15., Seite 1091-1110
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| Auteur principal: |
Xia, Fang
(Auteur) |
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| Autres auteurs: |
George, Stephen L,
Ning, Jing,
Li, Liang,
Huang, Xuelin |
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| Format: | Article en ligne
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| Langue: | English |
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| Publié: |
2021
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| Accès à la collection: | Journal of applied statistics
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| Sujets: | Journal Article
Adaptive design
Bayesian adaptive randomization
Biomarker
Classifier
Enrichment strategy
Precision medicine |
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