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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202100629
|2 doi
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|a pubmed24n1481.xml
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|a eng
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| 100 |
1 |
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|a Liang, Tingxizi
|e verfasserin
|4 aut
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| 245 |
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|a Adipocyte-Derived Anticancer Lipid Droplets
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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| 500 |
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Engineering of efficient and safe materials remains a challenge for cancer therapy. Here, the lipid droplet, an organelle in adipocytes, is demonstrated to be a controllable and biocompatible vehicle to deliver anticancer drugs. It is validated that isolated lipid droplets maintain their key physiological functions to interact with other organelles and augment the therapeutic effect of cancer photodynamic therapy by encapsulation with a lipid-conjugated photosensitizer (Pyrolipid) through a variety of pathways, including generation of reactive oxygen species (ROS); lipid peroxidation; and endoplasmic reticulum (ER) stress. As such, the IC50 value of Pyrolipid is reduced by 6.0-fold when loaded into the lipid droplet. Of note, in vivo results demonstrate that engineered lipid droplets induce significant inhibition of tumor growth with minimal side effects
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|a Journal Article
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|a drug delivery
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|a lipid droplets
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|a organelles
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|a photodynamic therapy
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|a Antineoplastic Agents
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Photosensitizing Agents
|2 NLM
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| 650 |
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|a Drug Carriers
|2 NLM
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| 700 |
1 |
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|a Wen, Di
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Guojun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chan, Amanda
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Zhaowei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Hongjun
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Zejun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Han, Xiao
|e verfasserin
|4 aut
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| 700 |
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|a Jiang, Liping
|e verfasserin
|4 aut
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| 700 |
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|a Zhu, Jun-Jie
|e verfasserin
|4 aut
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| 700 |
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|a Gu, Zhen
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 26 vom: 13. Juli, Seite e2100629
|w (DE-627)NLM098206397
|x 1521-4095
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|g volume:33
|g year:2021
|g number:26
|g day:13
|g month:07
|g pages:e2100629
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|u http://dx.doi.org/10.1002/adma.202100629
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