AaWRKY9 contributes to light- and jasmonate-mediated to regulate the biosynthesis of artemisinin in Artemisia annua

AaWRKY9 contributes to light- and jasmonate-mediated to regulate the biosynthesis of artemisinin in Artemisia annua

© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 231(2021), 5 vom: 10. Sept., Seite 1858-1874
1. Verfasser: Fu, Xueqing (VerfasserIn)
Weitere Verfasser: Peng, Bowen, Hassani, Danial, Xie, Lihui, Liu, Hang, Li, Yongpeng, Chen, Tiantian, Liu, Pin, Tang, Yueli, Li, Ling, Zhao, Jingya, Sun, Xiaofen, Tang, Kexuan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Artemisia annua AaWRKY9 artemisinin glandular trichomes jasmonate (JA) light signalling Artemisinins Cyclopentanes mehr... Oxylipins Plant Proteins jasmonic acid 6RI5N05OWW
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520 |a Artemisinin, isolated from Artemisia annua, is recommended as the preferred drug to fight malaria. Previous research showed that jasmonate (JA)-mediated promotion of artemisinin accumulation depended on light. However, the mechanism underlying the interaction of light and JA in regulating artemisinin accumulation is still unknown. We identified a WRKY transcription factor, AaWRKY9, using transcriptome analysis. The glandular trichome-specific AaWRKY9 positively regulates artemisinin biosynthesis by directly binding to the promoters of AaDBR2 and AaGSW1. The key regulator in the light pathway AaHY5 activates the expression of AaWRKY9 by binding to its promoter. In addition, AaWRKY9 interacts with AaJAZ9, a repressor in the JA signalling pathway. AaJAZ9 represses the transcriptional activation activity of AaWRKY9 in the absence of methyl jasmonate. Notably, in the presence of methyl jasmonate, the transcriptional activation activity of AaWRKY9 is increased. Taken together, our results reveal a novel molecular mechanism underlying AaWRKY9 contributes to light-mediated and jasmonate-mediated to regulate the biosynthesis of artemisinin in A. annua. Our study provides new insights into integrating the two signalling pathways to regulate terpene biosynthesis in plants 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Artemisia annua 
650 4 |a AaWRKY9 
650 4 |a artemisinin 
650 4 |a glandular trichomes 
650 4 |a jasmonate (JA) 
650 4 |a light signalling 
650 7 |a Artemisinins  |2 NLM 
650 7 |a Cyclopentanes  |2 NLM 
650 7 |a Oxylipins  |2 NLM 
650 7 |a Plant Proteins  |2 NLM 
650 7 |a jasmonic acid  |2 NLM 
650 7 |a 6RI5N05OWW  |2 NLM 
700 1 |a Peng, Bowen  |e verfasserin  |4 aut 
700 1 |a Hassani, Danial  |e verfasserin  |4 aut 
700 1 |a Xie, Lihui  |e verfasserin  |4 aut 
700 1 |a Liu, Hang  |e verfasserin  |4 aut 
700 1 |a Li, Yongpeng  |e verfasserin  |4 aut 
700 1 |a Chen, Tiantian  |e verfasserin  |4 aut 
700 1 |a Liu, Pin  |e verfasserin  |4 aut 
700 1 |a Tang, Yueli  |e verfasserin  |4 aut 
700 1 |a Li, Ling  |e verfasserin  |4 aut 
700 1 |a Zhao, Jingya  |e verfasserin  |4 aut 
700 1 |a Sun, Xiaofen  |e verfasserin  |4 aut 
700 1 |a Tang, Kexuan  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t The New phytologist  |d 1979  |g 231(2021), 5 vom: 10. Sept., Seite 1858-1874  |w (DE-627)NLM09818248X  |x 1469-8137  |7 nnns 
773 1 8 |g volume:231  |g year:2021  |g number:5  |g day:10  |g month:09  |g pages:1858-1874 
856 4 0 |u http://dx.doi.org/10.1111/nph.17453  |3 Volltext 
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