Effect of Multilayer Termination on Nonspecific Protein Adsorption and Antifouling Activity of Alginate-Based Layer-by-Layer Coatings

Layer-by-layer (LbL) assembly is a versatile platform for applying coatings and studying the properties of promising compounds for antifouling applications. Here, alginate-based LbL coatings were fabricated by alternating the deposition of alginic acid and chitosan or polyethylenimine to form multil...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 37(2021), 19 vom: 18. Mai, Seite 5950-5963
1. Verfasser: Gnanasampanthan, Thuvarakhan (VerfasserIn)
Weitere Verfasser: Beyer, Cindy D, Yu, Wenfa, Karthäuser, Jana F, Wanka, Robin, Spöllmann, Stephan, Becker, Hans-Werner, Aldred, Nick, Clare, Anthony S, Rosenhahn, Axel
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Alginates
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520 |a Layer-by-layer (LbL) assembly is a versatile platform for applying coatings and studying the properties of promising compounds for antifouling applications. Here, alginate-based LbL coatings were fabricated by alternating the deposition of alginic acid and chitosan or polyethylenimine to form multilayer coatings. Films were prepared with either odd or even bilayer numbers to investigate if the termination of the LbL coatings affects the physicochemical properties, resistance against the nonspecific adsorption (NSA) of proteins, and antifouling efficacy. The hydrophilic films, which were characterized using spectroscopic ellipsometry, water contact angle goniometry, ATR-FTIR spectroscopy, AFM, XPS, and SPR spectroscopy, revealed high swelling in water and strongly reduced the NSA of proteins compared to the hydrophobic reference. While the choice of the polycation was important for the protein resistance of the LbL coatings, the termination mattered less. The attachment of diatoms and settling of barnacle cypris larvae revealed good antifouling properties that were controlled by the termination and the charge density of the LbL films 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
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700 1 |a Beyer, Cindy D  |e verfasserin  |4 aut 
700 1 |a Yu, Wenfa  |e verfasserin  |4 aut 
700 1 |a Karthäuser, Jana F  |e verfasserin  |4 aut 
700 1 |a Wanka, Robin  |e verfasserin  |4 aut 
700 1 |a Spöllmann, Stephan  |e verfasserin  |4 aut 
700 1 |a Becker, Hans-Werner  |e verfasserin  |4 aut 
700 1 |a Aldred, Nick  |e verfasserin  |4 aut 
700 1 |a Clare, Anthony S  |e verfasserin  |4 aut 
700 1 |a Rosenhahn, Axel  |e verfasserin  |4 aut 
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