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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202008802
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|a eng
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| 100 |
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|a Zhang, Ming
|e verfasserin
|4 aut
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|a Upregulating Aggregation-Induced-Emission Nanoparticles with Blood-Tumor-Barrier Permeability for Precise Photothermal Eradication of Brain Tumors and Induction of Local Immune Responses
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|c 2021
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|a Text
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|a ƒaComputermedien
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Compared to other tumors, glioblastoma (GBM) is extremely difficult to treat. Recently, photothermal therapy (PTT) has demonstrated advanced therapeutic efficacy; however, because of the relatively low tissue-penetration efficiency of laser light, its application in deep-seated tumors remains challenging. Herein, bradykinin (BK) aggregation-induced-emission nanoparticles (BKAIE NPs) are synthesized; these offer selective penetration through the blood-tumor barrier (BTB) and strong absorbance in the near-infrared region (NIR). The BK ligand can prompt BTB adenosine receptor activation, which enhances transportation and accumulation inside tumors, as confirmed by T1 -weighted magnetic resonance and fluorescence imaging. The BK@AIE NPs exhibit high photothermal conversion efficiency under 980 nm NIR laser irradiation, facilitating the treatment of deep-seated tumors. Tumor progression can be effectively inhibited to extend the survival span of mice after spatiotemporal PTT. NIR irradiation can eradicate tumor tissues and release tumor-associated antigens. It is observed that the PTT treatment of GBM-bearing mice activates natural killer cells, CD3+ T cells, CD8+ T cells, and M1 macrophages in the GBM area, increasing the therapeutic efficacy. This study demonstrates that NIR-assisted BK@AIE NPs represent a promising strategy for the improved systematic elimination of GBMs and the activation of local brain immune privilege
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|a Journal Article
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|a glioblastoma
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| 650 |
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|a immune response
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4 |
|a magnetic resonance
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| 650 |
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4 |
|a photothermal therapy
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| 650 |
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|a Bradykinin
|2 NLM
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| 650 |
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|a S8TIM42R2W
|2 NLM
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| 700 |
1 |
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|a Wang, Wentao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mohammadniaei, Mohsen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Qicheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ashley, Jon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Shunjie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Ben Zhong
|e verfasserin
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 22 vom: 23. Juni, Seite e2008802
|w (DE-627)NLM098206397
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|g volume:33
|g year:2021
|g number:22
|g day:23
|g month:06
|g pages:e2008802
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|u http://dx.doi.org/10.1002/adma.202008802
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