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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202100595
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|a eng
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| 100 |
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|a Li, Shukun
|e verfasserin
|4 aut
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|a Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy
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|c 2021
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|a Text
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|a ƒaComputermedien
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a ErratumIn: Adv Mater. 2021 Jul;33(29):e2103733. doi: 10.1002/adma.202103733. - PMID 34288153
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Pancreatic cancer, one of the most lethal malignancies, compromises the performance of traditional therapeutic regimens in the clinic because of stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a biocompatible therapeutic paradigm that can effectively inhibit pancreatic tumor growth while simultaneously eliminating tumor metastasis is urgently needed. Herein, supramolecular nanofibrils are fabricated through coassembly of clinically approved immunomodulatory thymopentin and near-infrared indocyanine green for localized photothermal immunotherapy of pancreatic tumors. The resulting long-range ordered fibrous nanodrugs show improved photophysical capabilities for fluorescence imaging and photothermal conversion and significantly promote the proliferation and differentiation of antitumor immune cells. Hence, the integration of rapid photothermal therapy and moderate immunomodulation for inhibiting tumor growth and eliminating tumor metastasis is promising. The utilization of clinically approved molecules to construct nanodrugs administered via localized injection amplifies the complementary photothermal immunotherapeutic effects of the components, creating opportunities for clinical translation as a treatment for pancreatic cancer
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|a Journal Article
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|a cancer
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|a peptides
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|a photosensitizers
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|a photothermal immunotherapy
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|a self-assembly
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|a Indocyanine Green
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|a Antineoplastic Agents
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| 700 |
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|a Zhang, Wenjia
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|a Xing, Ruirui
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|a Yuan, Chengqian
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| 700 |
1 |
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|a Xue, Huadan
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| 700 |
1 |
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|a Yan, Xuehai
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 33(2021), 21 vom: 12. Mai, Seite e2100595
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