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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1111/vcp.12940
|2 doi
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|a pubmed25n1080.xml
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|a (DE-627)NLM324105134
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|a (NLM)33855710
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Moore, A Russell
|e verfasserin
|4 aut
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|a Diagnostic performance of routine electrophoresis and immunofixation for the detection of immunoglobulin paraproteins (M-Proteins) in dogs with multiple myeloma and related disorders
|b Part 2-Toward improved diagnostic performance
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1 |
|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 30.08.2021
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|a Date Revised 30.08.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 American Society for Veterinary Clinical Pathology.
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|a BACKGROUND: The diagnostic performance of routine electrophoresis (agarose gel electrophoresis [AGE] and capillary zone electrophoresis [CZE]) and species-specific immunofixation (IF) for the detection of immunoglobulin paraproteins (M-proteins) and diagnosis of secretory myeloma-related disorders (sMRD) can be improved. Available canine IF targets were IgG-FC, IgA, IgM, light chain (LC), IgG4, and free LC (fLC) antibodies
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|a OBJECTIVE: We aimed to review specific features associated with the presence of M-proteins in canine serum samples and the common features causing inaccurate reporting of M-proteins to improve the diagnostic performance of routine electrophoresis and IF for the detection of M-proteins
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|a METHODS: Features found in AGE, CZE, routine IF, IgG4 IF, and fLC IF of 100 canine serum samples from Part 1 of this study were evaluated by simple and multivariate logistic regression to identify factors associated with the presence of M-proteins. Cases falsely called negative or positive for M-proteins were reviewed to identify the common features that could be used to increase the diagnostic performance of SPE and IF for M-protein detection
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|a RESULTS: The presence of hypogammaglobulinemia or any peak taller than albumin was associated with an M-protein. Total protein concentrations, globulin concentrations, or peaks wider than albumin were not associated with an M-protein. Free LC sMRD cases were not diagnosed by SPE and routine IF. Cases with infectious and inflammatory etiologies had a restricted polyclonal gammopathy with multiple γ-globulin restrictions resulting in some false-positive results. SPE combined with all available IF results and the specific features identified in this study had an estimated sensitivity of 95.1% and specificity of 81.4%
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|a CONCLUSIONS: The identified criteria of this study increase the diagnostic performance of the electrophoretic evaluation for M-proteins
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|a Journal Article
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|a Review
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| 650 |
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|a Canis lupis familiaris
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| 650 |
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|a biclonal gammopathy
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| 650 |
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|a canine
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| 650 |
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|a ehrlichia
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| 650 |
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|a immunotyping
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| 650 |
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|a monoclonal gammopathy
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| 650 |
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|a Immunoglobulin Light Chains
|2 NLM
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| 650 |
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|a Paraproteins
|2 NLM
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| 700 |
1 |
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|a Harris, R Adam
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jeffries, Christina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ashton, Laura
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Avery, Paul R
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 50(2021), 2 vom: 15. Juni, Seite 249-258
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnas
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| 773 |
1 |
8 |
|g volume:50
|g year:2021
|g number:2
|g day:15
|g month:06
|g pages:249-258
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| 856 |
4 |
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|u http://dx.doi.org/10.1111/vcp.12940
|3 Volltext
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 50
|j 2021
|e 2
|b 15
|c 06
|h 249-258
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