An Enhanced Expression Level of CXCR3 on Tfh-like Cells from Lupus Skin Lesions Rather Than Lupus Peripheral Blood

An Enhanced Expression Level of CXCR3 on Tfh-like Cells from Lupus Skin Lesions Rather Than Lupus Peripheral Blood

Copyright © 2021 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 226(2021) vom: 01. Mai, Seite 108717
1. Verfasser: Yang, Ming (VerfasserIn)
Weitere Verfasser: Cao, Pengpeng, Zhao, Zhidan, Wang, Zheyu, Jia, Chen, Guo, Yunkai, Yin, Heng, Zhao, Ming, Ding, Yan, Wu, Haijing, Lu, Qianjin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't CCR4 CCR6 CXCR3 SLE Tfh CXCR3 protein, human Receptors, CCR4 Receptors, CCR6 Receptors, CXCR3
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520 |a Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, and the etiopathogenesis is unclear. Follicular helper T (Tfh) cells have been reported as an important pathogenic cell type in SLE. CXCR3 was reported to be decreased on lupus peripheral CD4+T cells. However, the expression level of CCR4, CCR6 and CXCR3 on Tfh-like cells in SLE peripheral blood and skin lesions is unknown. In this study, we detected CCR4, CCR6 and CXCR3 expression level on Tfh-like cells in the peripheral blood and skin lesions from SLE patients and normal controls (NCs). A decreased expression level of CXCR3 on Tfh-like cells was found in lupus peripheral blood. However, an increased CXCR3 expression was observed on total CD4+T and Tfh-like cells from lupus skin lesions. Moreover, we observed a higher expression level of CXCR3 in Tfh cells from human tonsils. These findings indicate that CXCR3 might help Tfh-like cells to migrate into the inflammatory sites 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a CCR4 
650 4 |a CCR6 
650 4 |a CXCR3 
650 4 |a SLE 
650 4 |a Tfh 
650 7 |a CXCR3 protein, human  |2 NLM 
650 7 |a Receptors, CCR4  |2 NLM 
650 7 |a Receptors, CCR6  |2 NLM 
650 7 |a Receptors, CXCR3  |2 NLM 
700 1 |a Cao, Pengpeng  |e verfasserin  |4 aut 
700 1 |a Zhao, Zhidan  |e verfasserin  |4 aut 
700 1 |a Wang, Zheyu  |e verfasserin  |4 aut 
700 1 |a Jia, Chen  |e verfasserin  |4 aut 
700 1 |a Guo, Yunkai  |e verfasserin  |4 aut 
700 1 |a Yin, Heng  |e verfasserin  |4 aut 
700 1 |a Zhao, Ming  |e verfasserin  |4 aut 
700 1 |a Ding, Yan  |e verfasserin  |4 aut 
700 1 |a Wu, Haijing  |e verfasserin  |4 aut 
700 1 |a Lu, Qianjin  |e verfasserin  |4 aut 
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773 1 8 |g volume:226  |g year:2021  |g day:01  |g month:05  |g pages:108717 
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