Associations of TNFA, IL17A, and RORC mRNA expression levels in peripheral blood leukocytes with obesity-related asthma in adolescents

Associations of TNFA, IL17A, and RORC mRNA expression levels in peripheral blood leukocytes with obesity-related asthma in adolescents

Copyright © 2021 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 229(2021) vom: 28. Aug., Seite 108715
1. Verfasser: Leija-Martínez, José J (VerfasserIn)
Weitere Verfasser: Del-Río-Navarro, Blanca E, Sanchéz-Muñoz, Fausto, Muñoz-Hernández, Onofre, Hong, Enrique, Giacoman-Martínez, Abraham, Romero-Nava, Rodrigo, Patricio-Román, Karla L, Hall-Mondragon, Margareth S, Espinosa-Velazquez, Dario, Villafaña, Santiago, Huang, Fengyang
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Asthma IL-17A Non-allergic asthma Obesity RORC Tumour necrosis factor-alpha Biomarkers IL17A protein, human mehr... Interleukin-17 Nuclear Receptor Subfamily 1, Group F, Member 3 RNA, Messenger RORC protein, human TNF protein, human Tumor Necrosis Factor-alpha
Beschreibung
Zusammenfassung:Copyright © 2021 Elsevier Inc. All rights reserved.
Obesity is associated with a unique non-T2 asthma phenotype, characterised by a Th17 immune response. Retinoid-related orphan receptor C (RORC) is the master transcription factor for Th17 polarisation. We investigated the association of TNFA, IL17A, and RORC mRNA expression levels with the non-T2 phenotype. We conducted a cross-sectional study in adolescents, subdivided as follows: healthy (HA), allergic asthma without obesity (AA), obesity without asthma (OB), and non-allergic asthma with obesity (NAO). TNFA, IL17A, and RORC mRNA expression in peripheral blood leukocytes were assessed by RT-PCR. NAO exhibited higher TNFA mRNA expression levels than HA or OB, as well as the highest IL17A and RORC mRNA expression levels among the four groups. The best biomarker for discriminating non-allergic asthma among obese adolescents was RORC mRNA expression levels (area under the curve: 0.95). RORC mRNA expression levels were associated with the non-T2 asthma phenotype, hinting at a therapeutic target in obesity-related asthma
Beschreibung:Date Completed 16.09.2021
Date Revised 16.09.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2021.108715