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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108714
|2 doi
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|a pubmed24n1076.xml
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|a (DE-627)NLM322979536
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|a (NLM)33741504
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|a (PII)S1521-6616(21)00051-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Albert Vega, Chloé
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Differential response induced by LPS and MPLA in immunocompetent and septic individuals
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 24.06.2021
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|a Date Revised 24.06.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Lipopolysaccharide (LPS) and monophosphoryl lipid A (MPLA) induce, overall, similar transcriptional profiles in healthy individuals, although LPS has been shown to more potently induce pro-inflammatory cytokines. We explore herein whether MPLA could be considered as a synthetic replacement of LPS in immune functional assays to study anergy of immune cells in septic patients. Ex vivo whole blood stimulation with MPLA revealed a lower induction of the TNFα secreted protein in 20 septic patients (SP) compared to 10 healthy volunteers (HV), in agreement with monocyte anergy. Principal component analysis of the 93-gene molecular response to MPLA and LPS stimulation found that the main variability was driven by stimulation in HV and by pathophysiology in SP. MPLA was a stronger inducer of the HLA family genes than LPS in both populations, arguing for divergent signalling pathways downstream of TLR-4. In addition, MPLA appeared to present a more informative stratification potential within the septic population
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|a Clinical Trial
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|a Journal Article
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|a Randomized Controlled Trial
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|a Immune functional assay
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|a LPS
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|a MPLA
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|a Sepsis
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|a Septic patients
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|a Stratification
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| 650 |
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|a Cytokines
|2 NLM
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|a Lipid A
|2 NLM
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| 650 |
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|a Lipopolysaccharides
|2 NLM
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|a Toll-Like Receptor 4
|2 NLM
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| 650 |
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a monophosphoryl lipid A
|2 NLM
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| 650 |
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|a MWC0ET1L2P
|2 NLM
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| 700 |
1 |
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|a Karakike, Eleni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bartolo, François
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mouton, William
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cerrato, Elisabeth
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brengel-Pesce, Karen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Giamarellos-Bourboulis, Evangelos J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mallet, François
|e verfasserin
|4 aut
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| 700 |
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|a Trouillet-Assant, Sophie
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 226(2021) vom: 30. Mai, Seite 108714
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:226
|g year:2021
|g day:30
|g month:05
|g pages:108714
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2021.108714
|3 Volltext
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