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20231225183146.0 |
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231225s2021 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1111/nph.17351
|2 doi
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|a pubmed24n1076.xml
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|a (DE-627)NLM322967139
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|a (NLM)33740256
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Chen, Ruibing
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Discovery and modulation of diterpenoid metabolism improves glandular trichome formation, artemisinin production and stress resilience in Artemisia annua
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| 264 |
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 04.06.2021
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|a Date Revised 04.06.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2021 The Authors New Phytologist © 2021 New Phytologist Foundation.
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|a Plants synthesize diverse diterpenoids with numerous functions in organ development and stress resistance. However, the role of diterpenoids in glandular trichome (GT) development and GT-localized biosynthesis in plants remains unknown. Here, the identification of 10 diterpene synthases (diTPSs) revealed the diversity of diterpenoid biosynthesis in Artemisia annua. Protein-protein interactions (PPIs) between AaKSL1 and AaCPS2 in the plastids highlighted their potential functions in modulating metabolic flux to gibberellins (GAs) or ent-isopimara-7,15-diene-derived metabolites (IDMs) through metabolic engineering. A phenotypic analysis of transgenic plants suggested a complex repertoire of diterpenoids in Artemisia annua with important roles in GT formation, artemisinin accumulation and stress resilience. Metabolic engineering of diterpenoids simultaneously increased the artemisinin yield and stress resistance. Transcriptome and metabolic profiling suggested that bioactive GA4 /GA1 promote GT formation. Collectively, these results expand our knowledge of diterpenoids and show the potential of diterpenoids to simultaneously improve both the GT-localized metabolite yield and stress resistance, in planta
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Artemisia annua
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| 650 |
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4 |
|a artemisinin
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| 650 |
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4 |
|a diterpenoids
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| 650 |
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4 |
|a glandular trichome
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| 650 |
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4 |
|a stress resistance
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| 650 |
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7 |
|a Artemisinins
|2 NLM
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| 650 |
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7 |
|a Gibberellins
|2 NLM
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| 650 |
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7 |
|a Plant Proteins
|2 NLM
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| 700 |
1 |
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|a Bu, Yuejuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ren, Junze
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pelot, Kyle A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Xiangyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Diao, Yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Wansheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zerbe, Philipp
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Lei
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 230(2021), 6 vom: 19. Juni, Seite 2387-2403
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:230
|g year:2021
|g number:6
|g day:19
|g month:06
|g pages:2387-2403
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| 856 |
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|u http://dx.doi.org/10.1111/nph.17351
|3 Volltext
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|c 06
|h 2387-2403
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