Avoiding Hemolytic Anemia by Understanding the Effect of the Molecular Architecture of Gemini Surfactants on Hemolysis

Hemolytic behavior of a series of different categories of Gemini surfactants was determined in their low concentration range. Cationic Gemini surfactants of different molecular architectures prove to be highly cytotoxic even at 0.1 mM. Anionic and amino acid-based Gemini surfactants were minimally c...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 37(2021), 12 vom: 30. März, Seite 3709-3720
1. Verfasser: Agarwal, Vandana (VerfasserIn)
Weitere Verfasser: Gupta, Vikas, Bhardwaj, Vimal Kumar, Singh, Kultar, Khullar, Poonam, Bakshi, Mandeep Singh
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Surface-Active Agents
LEADER 01000naa a22002652 4500
001 NLM32290367X
003 DE-627
005 20231225183028.0
007 cr uuu---uuuuu
008 231225s2021 xx |||||o 00| ||eng c
024 7 |a 10.1021/acs.langmuir.1c00154  |2 doi 
028 5 2 |a pubmed24n1076.xml 
035 |a (DE-627)NLM32290367X 
035 |a (NLM)33733792 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Agarwal, Vandana  |e verfasserin  |4 aut 
245 1 0 |a Avoiding Hemolytic Anemia by Understanding the Effect of the Molecular Architecture of Gemini Surfactants on Hemolysis 
264 1 |c 2021 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 21.06.2021 
500 |a Date Revised 21.06.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Hemolytic behavior of a series of different categories of Gemini surfactants was determined in their low concentration range. Cationic Gemini surfactants of different molecular architectures prove to be highly cytotoxic even at 0.1 mM. Anionic and amino acid-based Gemini surfactants were minimally cytotoxic, although their toxicity was concentration-dependent. With respect to monomeric surfactants of comparable hydrocarbon chain lengths, cationic Gemini surfactants were much more toxic than anionic Gemini surfactants. Incubation temperature was another important parameter that significantly drove the hemolysis irrespective of the molecular structure of the surfactant. Results indicated that the surface activity or liquid-blood cell membrane adsorption tendency of a surfactant molecule determined the degree of hemolytic anemia. Greater surface activity induced greater cytotoxicity, especially when the surfactant possessed a stronger ability to interact with the membrane proteins through hydrophilic interactions. That provided cationic Gemini surfactants a higher ability for hemolytic anemia because they were able to interact with an electronegative cell membrane with favorable interactions in comparison to anionic or amino acid-based Gemini surfactants. These findings are expected to help in designing surface-active drugs with a suitable molecular architecture that can avoid hemolytic anemia 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Surface-Active Agents  |2 NLM 
700 1 |a Gupta, Vikas  |e verfasserin  |4 aut 
700 1 |a Bhardwaj, Vimal Kumar  |e verfasserin  |4 aut 
700 1 |a Singh, Kultar  |e verfasserin  |4 aut 
700 1 |a Khullar, Poonam  |e verfasserin  |4 aut 
700 1 |a Bakshi, Mandeep Singh  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Langmuir : the ACS journal of surfaces and colloids  |d 1992  |g 37(2021), 12 vom: 30. März, Seite 3709-3720  |w (DE-627)NLM098181009  |x 1520-5827  |7 nnns 
773 1 8 |g volume:37  |g year:2021  |g number:12  |g day:30  |g month:03  |g pages:3709-3720 
856 4 0 |u http://dx.doi.org/10.1021/acs.langmuir.1c00154  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_22 
912 |a GBV_ILN_350 
912 |a GBV_ILN_721 
951 |a AR 
952 |d 37  |j 2021  |e 12  |b 30  |c 03  |h 3709-3720