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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202006902
|2 doi
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|a pubmed25n1075.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Chen, Hao
|e verfasserin
|4 aut
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|a Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 24.07.2024
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|a Date Revised 24.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2021 Wiley-VCH GmbH.
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|a Development of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes in the second near-infrared window (NIR-II, 1000-1700 nm) show high promise because of their exceptional high detection sensitivity, resolution, and deep imaging depth. Here, a sharp pH-sensitive self-assembling cyclopeptide-dye, SIMM1000, as a smart nanoprobe for NIR-II imaging of diseases in living animals, is reported. This small molecule assembled nanoprobe exhibits smart properties by responding to a sharp decrease of pH in the tumor microenvironment (pH 7.0 to 6.8), aggregating from small nanoprobe (80 nm at pH 7.0) into large nanoparticles (>500 nm at pH 6.8) with ≈20-30 times enhanced fluorescence compared with the non-self-assembled CH-4T. It yields micrometer-scale resolution in blood vessel imaging and high contrast and resolution in bone and tumor imaging in mice. Because of its self-aggregation in acidic tumor microenvironments in situ, SIMM1000 exhibits high tumor accumulation and extremely long tumor retention (>19 days), while being excretable from normal tissues and safe. This smart self-assembling small molecule strategy can shift the paradigm of designing new nanomaterials for molecular imaging and drug development
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|a Journal Article
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|a NIR-II fluorescence imaging
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|a fluorescence-imaging-guided tumor surgery
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|a pH-responsive materials
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|a self-assembly
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|a tumor imaging
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|a Peptides, Cyclic
|2 NLM
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| 650 |
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|a Fluorescent Dyes
|2 NLM
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| 700 |
1 |
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|a Shou, Kangquan
|e verfasserin
|4 aut
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1 |
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|a Chen, Si
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qu, Chunrong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Zhiming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Mark
|e verfasserin
|4 aut
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1 |
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|a Ding, Bingbing
|e verfasserin
|4 aut
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1 |
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|a Qian, Kun
|e verfasserin
|4 aut
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|a Ji, Aiyan
|e verfasserin
|4 aut
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1 |
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|a Lou, Hongyue
|e verfasserin
|4 aut
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1 |
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|a Tong, Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hsu, Alexander
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yuebing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Felsher, Dean W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Zhenhua
|e verfasserin
|4 aut
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| 700 |
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|a Tian, Jie
|e verfasserin
|4 aut
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| 700 |
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|a Cheng, Zhen
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 33(2021), 16 vom: 10. Apr., Seite e2006902
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:33
|g year:2021
|g number:16
|g day:10
|g month:04
|g pages:e2006902
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|u http://dx.doi.org/10.1002/adma.202006902
|3 Volltext
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