The HLA-DR4-DQ8 phenotype of the recipient is associated with increased mortality after kidney transplantation

The HLA-DR4-DQ8 phenotype of the recipient is associated with increased mortality after kidney transplantation

Copyright © 2021 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 226(2021) vom: 25. Mai, Seite 108711
1. Verfasser: Lund, Kit P (VerfasserIn)
Weitere Verfasser: Eriksson, Frank, Hauge, Anne W, Mora-Jensen, Helena I, Sørensen, Søren S, Bruunsgaard, Helle
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't HLA Inflammation Kidney transplantation Mortality Biomarkers HLA Antigens HLA-DR4 Antigen
Beschreibung
Zusammenfassung:Copyright © 2021 Elsevier Inc. All rights reserved.
The importance of the human leukocyte antigen (HLA) system in kidney transplantation is well-known, but it remains unexplored if patient HLA antigens constitute independent risk factors in complications after transplantation. We hypothesized that specific HLA class II phenotypes associated with immune-mediated disease (HLA-IMD) predispose to immunological activity and/or complications after kidney transplantation. Based on the literature we defined HLA-DR2-DQ6; -DR3-DQ2 and -DR4-DQ8 as HLA-IMD phenotypes. We investigated associations between HLA-IMD phenotypes in patients, biomarkers of systemic chronic inflammation at the time of transplantation, and the outcome after kidney transplantation in a retrospective cohort study of 611 kidney transplanted patients. The HLA-IMD phenotypes were associated with higher levels of biomarkers of systemic inflammation. The HLA-DR4-DQ8 phenotype was associated with mortality after transplantation in Cox analyses with adjustments for confounders. Data support the hypothesis that specific HLA class II phenotypes affects immunological pathways that determine the midterm clinical outcome of kidney transplantation
Beschreibung:Date Completed 24.06.2021
Date Revised 24.06.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2021.108711