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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108698
|2 doi
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|a pubmed24n1073.xml
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|a (DE-627)NLM321971825
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|a (NLM)33639275
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|a (PII)S1521-6616(21)00035-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Subburayalu, Julien
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Characterization of follicular T helper cells and donor-specific T helper cells in renal transplant patients with de novo donor-specific HLA-antibodies
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| 264 |
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 24.06.2021
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| 500 |
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|a Date Revised 24.06.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 Elsevier Inc. All rights reserved.
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|a T follicular helper (TFH) cells are a heterogeneous subset of immunocompetent T helper (TH) cells capable of augmenting B cell responses in lymphoid tissues. In transplantation, exposure to allogeneic tissue activates TFH cells increasing the risk of the emergence of de novo donor-specific HLA-antibodies (dnDSA). These can cause antibody-mediated rejection (AMR) and allograft loss. Follicular regulatory T (TFR) cells counteract TFH cell activity. Here, we investigated the implications of TFH and TFR cells on dnDSA formation after renal transplantation (RTX). Considering TFH cells to be CXCR5+ and IL-21+, we found by flow cytometry that patients with dnDSA produced IL-21 more abundantly compared to healthy volunteers. In in vitro alloreactivity assays, patients with dnDSA featured an enhanced alloreactive TH cell pool in response to donor-specific HLA antigens. Besides, longitudinal investigations suggested enhanced alloreactivity shortly after transplantation increasing the risk of dnDSA development. Taken together, in spite of continuous immunosuppression we report a strong IL-21 response in TFH cells and an expanded reservoir of donor-specific memory TH cells in patients with dnDSA. This warrants further investigations if aberrant TFH cell activation may precede the formation of dnDSA promoting AMR
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4 |
|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Allospecific T cell reactivity
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| 650 |
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4 |
|a Antibody-mediated rejection
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| 650 |
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4 |
|a Solid organ transplantation
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| 650 |
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4 |
|a T follicular helper cell
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| 650 |
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4 |
|a T follicular regulatory cell
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| 650 |
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4 |
|a de novo donor-specific HLA-antibodies
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| 650 |
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7 |
|a Antibodies
|2 NLM
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| 650 |
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7 |
|a HLA Antigens
|2 NLM
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| 650 |
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7 |
|a Interleukins
|2 NLM
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| 650 |
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7 |
|a Receptors, CXCR5
|2 NLM
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| 650 |
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7 |
|a interleukin-21
|2 NLM
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| 650 |
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7 |
|a MKM3CA6LT1
|2 NLM
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| 700 |
1 |
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|a Dolff, Sebastian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Shilei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lindemann, Monika
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Heinold, Andreas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Heinemann, Falko M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tervaert, Jan Willem Cohen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Eisenberger, Ute
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Korth, Johannes
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brinkhoff, Alexandra
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kribben, Andreas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Witzke, Oliver
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wilde, Benjamin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 226(2021) vom: 07. Mai, Seite 108698
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:226
|g year:2021
|g day:07
|g month:05
|g pages:108698
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2021.108698
|3 Volltext
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|a GBV_ILN_11
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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|d 226
|j 2021
|b 07
|c 05
|h 108698
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