|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM321460669 |
| 003 |
DE-627 |
| 005 |
20231225175843.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2021 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/acs.langmuir.0c03483
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1071.xml
|
| 035 |
|
|
|a (DE-627)NLM321460669
|
| 035 |
|
|
|a (NLM)33586439
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Ma, Haijun
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Cellular Uptake, Organelle Enrichment, and In Vitro Antioxidation of Fullerene Derivatives, Mediated by Surface Charge
|
| 264 |
|
1 |
|c 2021
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 21.06.2021
|
| 500 |
|
|
|a Date Revised 21.06.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Hydrophilic fullerene derivatives get notable performance in various biological applications, especially in cancer therapy and antioxidation. The biological behaviors of functional fullerenes are much dependent on their surface physicochemical properties. The excellent reactive oxygen species-scavenging capabilities of functional fullerenes promote their outstanding performances in inhibiting pathological symptoms associated with oxidative stress, including neurodegenerative diseases, cardiovascular diseases, acute and chronic kidney disease, and diabetes. Herein, fullerene derivatives with reversed surface charges in aqueous solutions are prepared: cationic C60-EDA and anionic C60-(EDA-EA). Under the driving force of membrane potential (negative inside) in the cell and mitochondria, C60-EDA is much rapidly taken in by cells and transported into mitochondria compared with C60-(EDA-EA) that is enriched in lysosomes. With high cellular uptake and mitochondrial enrichment, C60-EDA exhibits stronger antioxidation capabilities in vitro than C60-(EDA-EA), indicating its better performance in the therapy of oxidation-induced diseases. It is revealed that the cellular uptake rate, subcellular location, and intracellular antioxidation behavior of fullerene derivatives are primarily mediated by their surface charges, providing new strategies for the design of fullerene drugs and their biological applications
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Antioxidants
|2 NLM
|
| 650 |
|
7 |
|a Fullerenes
|2 NLM
|
| 650 |
|
7 |
|a Reactive Oxygen Species
|2 NLM
|
| 700 |
1 |
|
|a Zhang, Xiaoyan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yang, Yang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Shumu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Huo, Jiawei
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Yang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Guan, Mirong
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhen, Mingming
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Shu, Chunying
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Jie
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Chunru
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 37(2021), 8 vom: 02. März, Seite 2740-2748
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:37
|g year:2021
|g number:8
|g day:02
|g month:03
|g pages:2740-2748
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/acs.langmuir.0c03483
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 37
|j 2021
|e 8
|b 02
|c 03
|h 2740-2748
|