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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c03250
|2 doi
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|a pubmed24n1071.xml
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|a eng
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|a Zhou, Yimin
|e verfasserin
|4 aut
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|a Hyaluronic Acid-Functionalized Hollow Mesoporous Silica Nanoparticles as pH-Sensitive Nanocarriers for Cancer Chemo-Photodynamic Therapy
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 21.06.2021
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|a Date Revised 21.06.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Hollow mesoporous silica nanoparticles (HMSNs) served as nanocarriers for transporting doxorubicin hydrochloride (DOX) and indocyanine green (ICG) and were incorporated into a pH-sensitive targeted drug delivery system (DDS). Boronate ester bonds were employed to link HMSNs and dopamine-modified hyaluronic acid (DA-HA), which acted as both the "gatekeeper" and targeting agents (HMSNs-B-HA). Well-dispersed HMSNs-B-HA with a diameter of about 170 nm was successfully constructed. The conclusion was drawn from the in vitro drug release experiment that ICG and DOX (ID) co-loaded nanoparticles (IDHMSNs-B-HA) with high drug loading efficiency could sustain drug release under acidic conditions. More importantly, in vitro cell experiments perfectly showed that ID@HMSNs-B-HA could well inhibit murine mammary carcinoma (4T1) cells via chemotherapy combined with photodynamic therapy and accurately target 4 T1 cells. In summary, all test results sufficiently demonstrated that the prepared ID@HMSNs-B-HA was a promising nano-DDS for cancer photodynamic combined with chemotherapy
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Silicon Dioxide
|2 NLM
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|a 7631-86-9
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|a Doxorubicin
|2 NLM
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|a 80168379AG
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|a Hyaluronic Acid
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|a 9004-61-9
|2 NLM
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| 700 |
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|a Chang, Cong
|e verfasserin
|4 aut
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|a Liu, Zuhao
|e verfasserin
|4 aut
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|a Zhao, Qiuling
|e verfasserin
|4 aut
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|a Xu, Qingni
|e verfasserin
|4 aut
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|a Li, Chaohua
|e verfasserin
|4 aut
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|a Chen, Yuqi
|e verfasserin
|4 aut
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|a Zhang, Yueli
|e verfasserin
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|a Lu, Bo
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 37(2021), 8 vom: 02. März, Seite 2619-2628
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:37
|g year:2021
|g number:8
|g day:02
|g month:03
|g pages:2619-2628
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|u http://dx.doi.org/10.1021/acs.langmuir.0c03250
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