Photo-catalyzed TiO2 inactivates pathogenic viruses by attacking viral genome
© 2021 Elsevier B.V. All rights reserved.
| Veröffentlicht in: | Chemical engineering journal (Lausanne, Switzerland : 1996). - 1999. - 414(2021) vom: 15. Juni, Seite 128788 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2021
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| Zugriff auf das übergeordnete Werk: | Chemical engineering journal (Lausanne, Switzerland : 1996) |
| Schlagworte: | Journal Article Inactivate Pathogenic viruses Photocatalyst TiO2 |
| Zusammenfassung: | © 2021 Elsevier B.V. All rights reserved. Previous observations have been reported that viruses were inactivated using strong irradiation. Here, new evidence was disclosed by studying the effects of nanosized TiO2 on viral pathogens under a low irradiation condition (0.4 mW/cm2 at UVA band) that mimics the field setting. We showed that photo-activated TiO2 efficiently inhibits hepatitis C virus infection, and weak indoor light with intensity of 0.6 mW/cm2 at broad-spectrum wavelength and around 0.15 mW/cm2 of UVA band also lead to partial inhibition. Mechanistic studies demonstrated that hydroxyl radicals produced by photo-activated TiO2 do not destroy virion structure and contents, but attack viral RNA genome, thus inactivating the virus. Furthermore, we showed that photo-activated TiO2 inactivates a broad range of human viral pathogens, including SARS-CoV-2, a novel coronavirus responsible for the ongoing COVID-19 pandemic. In conclusion, we showed that photo-catalyzed nanosized TiO2 inactivates pathogenic viruses, paving a way to its field application in control of viral infectious diseases |
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| Beschreibung: | Date Revised 08.09.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
| ISSN: | 1385-8947 |
| DOI: | 10.1016/j.cej.2021.128788 |