Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised)

Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised)

This is a work of the US government and distributed under the terms of the Public Domain.

Bibliographische Detailangaben
Veröffentlicht in:National Toxicology Program technical report series. - 1979. - (2020), 598 vom: 08. Mai
1. Verfasser: National Toxicology Program (VerfasserIn)
Weitere Verfasser: Blystone, C R (BerichterstatterIn), Herbert, R A (BerichterstatterIn), Janardhan, K S (BerichterstatterIn), Adams, E T (BerichterstatterIn), Brix, A E (BerichterstatterIn), Burback, B L (BerichterstatterIn), Co, C (BerichterstatterIn), Contos, D A (BerichterstatterIn), Cora, M C (BerichterstatterIn), Crabbs, T A (BerichterstatterIn), Cristy, T A (BerichterstatterIn), Cunny, H C (BerichterstatterIn), Fostel, J M (BerichterstatterIn), Gerken, D K (BerichterstatterIn), Graves, S W (BerichterstatterIn), Hejtmancik, M R (BerichterstatterIn), Hoane, J (BerichterstatterIn), Hooth, M J (BerichterstatterIn), Jokinen, M (BerichterstatterIn), Pierfelice, J (BerichterstatterIn), King-Herbert, A P (BerichterstatterIn), Krause, J (BerichterstatterIn), Lu, Y I (BerichterstatterIn), Malarkey, D E (BerichterstatterIn), McBride, S (BerichterstatterIn), McIntyre, B S (BerichterstatterIn), Roberts, G K (BerichterstatterIn), Robinson, V G (BerichterstatterIn), Ryan, M J (BerichterstatterIn), Shockley, K R (BerichterstatterIn), Smith-Roe, S L (BerichterstatterIn), Snyder, E M (BerichterstatterIn), South, N L (BerichterstatterIn), Stout, M D (BerichterstatterIn), Travlos, G S (BerichterstatterIn), Vasconcelos, D Y (BerichterstatterIn), Waidyanatha, S (BerichterstatterIn), Walker, N J (BerichterstatterIn), Watson, A (BerichterstatterIn), Witt, K L (BerichterstatterIn)
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:National Toxicology Program technical report series
Schlagworte:Journal Article Technical Report
Beschreibung
Zusammenfassung:This is a work of the US government and distributed under the terms of the Public Domain.
Perfluorooctanoic acid (PFOA) is a perfluorinated alkyl substance (PFAS) with widespread exposure in the environment and human population. Lifetime exposure to this chemical is likely, which includes in utero and postnatal development. Previously conducted chronic carcinogenicity studies of PFOA began exposure after these critical periods of development, so it is unknown whether the carcinogenic response is altered if exposure during gestation and lactation is included. The current PFOA chronic studies were designed to assess the contribution of combined gestational and lactational exposure (herein referred to as perinatal exposure) to the chronic toxicity and carcinogenicity of PFOA. The hypothesis tested was that including exposure during gestation and lactation (perinatal exposure) with postweaning exposure would change the PFOA carcinogenic response quantitatively (more neoplasms) or qualitatively (different neoplasm types) compared to postweaning exposure alone. (Abstract Abridged)
Beschreibung:Date Completed 07.10.2021
Date Revised 24.07.2024
published: Print
Citation Status PubMed-not-MEDLINE
ISSN:0888-8051
DOI:10.22427/NTP-TR-598