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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108683
|2 doi
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|a pubmed25n1070.xml
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|a (NLM)33549832
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Li, Chaoran
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Aberrant monocyte subsets in patients with Behçet's disease
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| 264 |
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|c 2021
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|a Date Completed 11.06.2021
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|a Date Revised 11.06.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 Elsevier Inc. All rights reserved.
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|a Monocytes are a versatile and dynamic population, but its implication in Behçet's Disease (BD) remains elusive. We investigated the proportion, phenotypical and functional alterations in classical monocytes (CM), intermediate monocytes (IM) and non-classical monocytes (NCM) subsets in BD. A higher IM and lower NCM population in BD patients were noted, closely correlated with disease activity, and rescued after treatment. CD11b and CD64 expression on CM, IM and NCM in BD were enhanced. BD CM promoted TNF-a and IL-6 production and facilitated Th1 differentiation. BD IM promoted IL-6 production. We further demonstrated a higher level of phosphorylated p65 (p-p65) in BD CM and increased p-p65 and p-p38 in BD IM. Our data highlighted the aberrant populations of IM and CM in BD, potentially implicated in BD' pathogenesis
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Behçet's disease
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4 |
|a Monocyte subsets
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|a CD11b Antigen
|2 NLM
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a Inflammation Mediators
|2 NLM
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| 650 |
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|a Receptors, IgG
|2 NLM
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| 700 |
1 |
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|a Liu, Jinjing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Xin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Zhimian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Xiaofeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Fengchun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Wenjie
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 225(2021) vom: 01. Apr., Seite 108683
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
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|g volume:225
|g year:2021
|g day:01
|g month:04
|g pages:108683
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|u http://dx.doi.org/10.1016/j.clim.2021.108683
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