Remote Control of Time-Regulated Stretching of Ligand-Presenting Nanocoils In Situ Regulates the Cyclic Adhesion and Differentiation of Stem Cells

Remote Control of Time-Regulated Stretching of Ligand-Presenting Nanocoils In Situ Regulates the Cyclic Adhesion and Differentiation of Stem Cells

© 2021 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 11 vom: 15. März, Seite e2008353
1. Verfasser: Min, Sunhong (VerfasserIn)
Weitere Verfasser: Ko, Min Jun, Jung, Hee Joon, Kim, Wonsik, Han, Seong-Beom, Kim, Yuri, Bae, Gunhyu, Lee, Sungkyu, Thangam, Ramar, Choi, Hyojun, Li, Na, Shin, Jeong Eun, Jeon, Yoo Sang, Park, Hyeon Su, Kim, Yu Jin, Sukumar, Uday Kumar, Song, Jae-Jun, Park, Seung-Keun, Yu, Seung-Ho, Kang, Yun Chan, Lee, Ki-Bum, Wei, Qiang, Kim, Dong-Hwee, Han, Seung Min, Paulmurugan, Ramasamy, Kim, Young Keun, Kang, Heemin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article in vivo cell adhesion nanocoil pitch control remote control stem cell differentiation time-regulated ligand stretching Ligands arginyl-glycyl-aspartic acid 78VO7F77PN Oligopeptides Integrins
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245 1 0 |a Remote Control of Time-Regulated Stretching of Ligand-Presenting Nanocoils In Situ Regulates the Cyclic Adhesion and Differentiation of Stem Cells 
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520 |a Native extracellular matrix (ECM) can exhibit cyclic nanoscale stretching and shrinking of ligands to regulate complex cell-material interactions. Designing materials that allow cyclic control of changes in intrinsic ligand-presenting nanostructures in situ can emulate ECM dynamicity to regulate cellular adhesion. Unprecedented remote control of rapid, cyclic, and mechanical stretching ("ON") and shrinking ("OFF") of cell-adhesive RGD ligand-presenting magnetic nanocoils on a material surface in five repeated cycles are reported, thereby independently increasing and decreasing ligand pitch in nanocoils, respectively, without modulating ligand-presenting surface area per nanocoil. It is demonstrated that cyclic switching "ON" (ligand nanostretching) facilitates time-regulated integrin ligation, focal adhesion, spreading, YAP/TAZ mechanosensing, and differentiation of viable stem cells, both in vitro and in vivo. Fluorescence resonance energy transfer (FRET) imaging reveals magnetic switching "ON" (stretching) and "OFF" (shrinking) of the nanocoils inside animals. Versatile tuning of physical dimensions and elements of nanocoils by regulating electrodeposition conditions is also demonstrated. The study sheds novel insight into designing materials with connected ligand nanostructures that exhibit nanocoil-specific nano-spaced declustering, which is ineffective in nanowires, to facilitate cell adhesion. This unprecedented, independent, remote, and cytocompatible control of ligand nanopitch is promising for regulating the mechanosensing-mediated differentiation of stem cells in vivo 
650 4 |a Journal Article 
650 4 |a in vivo cell adhesion 
650 4 |a nanocoil pitch control 
650 4 |a remote control 
650 4 |a stem cell differentiation 
650 4 |a time-regulated ligand stretching 
650 7 |a Ligands  |2 NLM 
650 7 |a arginyl-glycyl-aspartic acid  |2 NLM 
650 7 |a 78VO7F77PN  |2 NLM 
650 7 |a Oligopeptides  |2 NLM 
650 7 |a Integrins  |2 NLM 
700 1 |a Ko, Min Jun  |e verfasserin  |4 aut 
700 1 |a Jung, Hee Joon  |e verfasserin  |4 aut 
700 1 |a Kim, Wonsik  |e verfasserin  |4 aut 
700 1 |a Han, Seong-Beom  |e verfasserin  |4 aut 
700 1 |a Kim, Yuri  |e verfasserin  |4 aut 
700 1 |a Bae, Gunhyu  |e verfasserin  |4 aut 
700 1 |a Lee, Sungkyu  |e verfasserin  |4 aut 
700 1 |a Thangam, Ramar  |e verfasserin  |4 aut 
700 1 |a Choi, Hyojun  |e verfasserin  |4 aut 
700 1 |a Li, Na  |e verfasserin  |4 aut 
700 1 |a Shin, Jeong Eun  |e verfasserin  |4 aut 
700 1 |a Jeon, Yoo Sang  |e verfasserin  |4 aut 
700 1 |a Park, Hyeon Su  |e verfasserin  |4 aut 
700 1 |a Kim, Yu Jin  |e verfasserin  |4 aut 
700 1 |a Sukumar, Uday Kumar  |e verfasserin  |4 aut 
700 1 |a Song, Jae-Jun  |e verfasserin  |4 aut 
700 1 |a Park, Seung-Keun  |e verfasserin  |4 aut 
700 1 |a Yu, Seung-Ho  |e verfasserin  |4 aut 
700 1 |a Kang, Yun Chan  |e verfasserin  |4 aut 
700 1 |a Lee, Ki-Bum  |e verfasserin  |4 aut 
700 1 |a Wei, Qiang  |e verfasserin  |4 aut 
700 1 |a Kim, Dong-Hwee  |e verfasserin  |4 aut 
700 1 |a Han, Seung Min  |e verfasserin  |4 aut 
700 1 |a Paulmurugan, Ramasamy  |e verfasserin  |4 aut 
700 1 |a Kim, Young Keun  |e verfasserin  |4 aut 
700 1 |a Kang, Heemin  |e verfasserin  |4 aut 
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773 1 8 |g volume:33  |g year:2021  |g number:11  |g day:15  |g month:03  |g pages:e2008353 
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